UCI
School of Biological Sciences
Developmental and Cell Biology

Carrie Baker-Brachmann

Carrie Brachmann, PhD

Carrie Baker-Brachmann, Ph.D.
Assistant Professor

2214 Natural Sciences I
University of California Irvine
Irvine, CA 92697

Tel: (949) 824-9139
Fax: (949) 824-4709
Email: cbrachma@uci.edu
Website: Lab Homepage

Spatial and molecular regulation of developmental apoptosis - My laboratory is using Drosophila as a model organism to address issues that are central to our understanding of apoptosis. The apoptotic machinery, inherent to each cell, is kept in a poised but inactive state. We are interested in how this intrinsic machinery is regulated in the developing organism, in response to both developmental cues and cellular damage.

Recent Publications

  • Brachmann, C.B. and Cagan, R.L. (in press). Patterning the Fly Eye: the Role of Apoptosis, [Review] Trends in Genetics.
  • Gorski, S.M., Brachmann, C.B., Tanenbaum, S.B., Cagan R.L. Delta and Notch promote correct localization of IrreC-rst. Cell Death and Diff. 7, 1011-1013.
  • Spencer, S., Brachmann, C.B., Cagan, R.L. (2000). “Drosophila Retinal Patterning”, [Review] Encyclopedia of Life Sciences. www.els.net Macmillan Publishers, Ltd., England.
  • Brachmann, C.B., Jassim, O.W., Wachsmuth, B.D., Cagan, R.L. (2000). The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr Biol. 10, 547-550.
  • Brachmann, C.B., Davies, A., Caputo, E., Cost, G., Li, J., Hieter, P., Boeke, J.D. (1998). Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains for PCR-mediated gene disruption and other applications. Yeast 14, 115-132.