Current advances in microfluidic platforms for single-cell evaluation in most cancers biology, analysis and remedy
Understanding molecular, mobile, genetic and purposeful heterogeneity of tumors on the single-cell stage has change into a serious problem for most cancers analysis. The microfluidic approach has emerged as an essential device that gives benefits in analyzing single-cells with the aptitude to combine time-consuming and labour-intensive experimental procedures akin to single-cell seize right into a single microdevice comfy and in a high-throughput vogue. Single-cell manipulation and evaluation may be applied inside a multi-functional microfluidic machine for varied purposes in most cancers analysis. Right here, we current latest advances of microfluidic gadgets for single-cell evaluation pertaining to most cancers biology, diagnostics, and therapeutics.We first concisely introduce varied microfluidic platforms used for single-cell evaluation, adopted with completely different microfluidic methods for single-cell manipulation. Then, we spotlight their varied purposes in most cancers analysis, with an emphasis on most cancers biology, analysis, and remedy. Present limitations and potential developments of microfluidic single-cell evaluation are mentioned on the finish.
4D CellBiology: Adaptive optics lattice light-sheet imaging and AI powered large information processing of reside stem cell-derived organoids
New strategies in stem cell 3D organoid tissue tradition, superior imaging, and massive information picture analytics now enable tissue-scale 4D cell biology however at present obtainable analytical pipelines are insufficient for handing and analyzing the ensuing gigabytes and terabytes of high-content imaging information.
We expressed fluorescent protein fusions of clathrin and dynamin2 at endogenous ranges in genome- edited human embryonic stem cells, which had been differentiated into intestinal epithelial organoids.
Lattice light-sheet imaging with adaptive optics (AO-LLSM) allowed us to picture giant volumes of those organoids (70 × 60 × 40 μm xyz) at 5.7 s/body.
We developed an open-source information evaluation package deal termed pyLattice to course of the ensuing giant (∼60 Gb) film information units and to trace clathrin-mediated endocytosis (CME) occasions.
We then expressed fluorescent protein fusions of actin and tubulin in genome-edited induced human pluripotent stem cells, which had been differentiated into human cortical organoids.
Utilizing the AO-LLSM mode on the brand new MOSAIC (Multimodal Optical Scope with Adaptive Imaging Correction) allowed us to picture neuronal migration deep within the organoid.
We augmented pyLattice with a deep studying module and used it to course of the mind organoid information.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from tissue homogenates, cell lysates or other biological fluids.
Description: A monoclonal antibody for detection of Myc-Tag from Null. This Myc-Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc-Tag from Null. This Myc-Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc-Tag from Null. This Myc-Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc-Tag from Null. This Myc-Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc-Tag from Null. This Myc-Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc-Tag from Null. This Myc-Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc-tag from Null. This Myc-tag antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen Myc synthetic peptide conjugated to KLH
Description: A polyclonal antibody for detection of Myc-tag from Null. This Myc-tag antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen Myc synthetic peptide conjugated to KLH
Description: A polyclonal antibody for detection of Myc-tag from Null. This Myc-tag antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen Myc synthetic peptide conjugated to KLH
Description: Mouse Anti-Myc Tag Monoclonal Antibody is Protein A purified and provided at 1 mg/mL. Suitable for Western blot or Immunostaining. 100 µg.
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB, IF, IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB, IF, IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB, IF, IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 350. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 405. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 488. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 555. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 594. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 647. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to AbFluor? 680. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Agarose. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Agarose. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Agarose. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Cy3. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Cy5. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IF. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to FITC. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Magnetic Beads. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Magnetic Beads. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for IP. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to Magnetic Beads. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to HRP. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to HRP. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A monoclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from mouse ascites by affinity-chromatography using the specific immunogen and conjugated to HRP. The antibody is produced in mouse by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogen and conjugated to HRP. The antibody is produced in rabbit by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogen and conjugated to HRP. The antibody is produced in rabbit by using as an immunogen synthetic peptide
Description: A polyclonal antibody for detection of Myc Tag from Null. This Myc Tag antibody is for WB. It is affinity-purified from rabbit antiserum by affinity-chromatography using the specific immunogen and conjugated to HRP. The antibody is produced in rabbit by using as an immunogen synthetic peptide
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is not conjugated.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 390.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 488.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 565.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 594.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 633.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 655.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 680.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with ATTO 700.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Alkaline Phosphatase.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with APC.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with APC/Cy7.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Biotin.
Description: A monoclonal antibody from clone 5D6 against Human | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Dylight 350.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Dylight 405.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Dylight 488.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Dylight 594.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Dylight 633.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with FITC.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with HRP.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with PE/ATTO 594.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with PerCP.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with RPE.
Description: A monoclonal antibody from clone 5D6 against Human | Mouse | Rat Myc Tag. The host species for the production of this antibody is Mouse. The antigen used for immunization is Human A synthetic peptide EQKLISEEDL coupled to KLH.. The antibody is tested and validated for WB, IP, ICC/IF assays with the following recommended dilutions: WB (1:10000), IP (1:200), ICC/IF (1:1000). This MAb for Myc Tag is conjugated with Streptavidin.
Description: A sandwich quantitative ELISA assay kit for detection of Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from tissue homogenates, cell lysates or other biological fluids.
Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Human V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from tissue homogenates, cell lysates or other biological fluids.
Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) ELISA Kit
Description: A sandwich quantitative ELISA assay kit for detection of Rat V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.
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Frequent Sources of Irritation and Their Influence on Hematopoietic Stem CellBiology
Function of evaluation: Inflammatory indicators have emerged as crucial regulators of hematopoietic stem cell (HSC) operate. Particularly, HSCs are extremely aware of acute modifications in systemic irritation and this influences not solely their division price but additionally their lineage destiny.
Figuring out how irritation regulates HSCs and shapes the blood system is essential to understanding the mechanisms underpinning these processes, in addition to potential hyperlinks between them.
Current findings: A widening array of physiologic and pathologic processes involving heightened irritation at the moment are acknowledged to critically have an effect on HSC biology and blood lineage manufacturing.
Circumstances documented to have an effect on HSC operate embody not solely acute and continual infections but additionally autoinflammatory circumstances, irradiation damage, and physiologic states akin to growing old and weight problems.
Abstract: Recognizing the contexts throughout which irritation impacts primitive hematopoiesis is important to enhancing our understanding of HSC biology and informing new therapeutic interventions towards maladaptive hematopoiesis that happens throughout inflammatory ailments, infections, and cancer-related issues. Key phrases: Bone marrow; Hematopoiesis; Infectious ailments; Inflammatory circumstances; Professional-inflammatory cytokines.
The crucial position of germinal center-associated nuclear protein (GANP) in cellbiology, immunohematology, and hematolymphoid oncogenesis
Germinal center-associated nuclear protein (GANP) is a singular and multifunctional protein that performs a crucial position in cell biology, neurodegenerative issues, immunohematology, and oncogenesis.
GANP is an orthologue of Saccharomyces Sac3, one of many elements of the TREX-2 advanced and a messenger RNA (mRNA) nuclear export issue. GANP is broadly conserved in all mammals, together with people.
Though GANP was initially found as a molecule upregulated within the germinal facilities of secondary lymphoid follicles in peripheral lymphoid organs, it’s expressed ubiquitously in lots of tissues.
It serves quite a few capabilities, together with making up a part of the mammalian TREX-2 advanced; mRNA nuclear export through nuclear pores; prevention of R-loop formation, genomic instability, and hyperrecombination; and B-cell affinity maturation.
On this evaluation, we first overview the in depth analyses which have revealed the essential capabilities of GANP and its ancestor molecule Sac3, together with mRNA nuclear export and regulation of R-loop formation.
We then describe how aberrant expression of GANP is considerably related to most cancers growth.
Furthermore, we focus on a vital position for GANP in B-cell growth, particularly affinity maturation in germinal facilities.
Lastly, we exhibit that overexpression of GANP in B cells results in lymphomagenesis resembling Hodgkin lymphoma derived from germinal heart B cells, and that GANP could also be concerned in transdifferentiation of B cells to macrophages, which strongly impacts Hodgkin lymphomagenesis.
Description: PPY belongs to the NPY family and is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa.
Description: A competitive ELISA for quantitative measurement of Human Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Human Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Goat Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Canine Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rabbit Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Porcine Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Mouse Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Rat Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Monkey Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Pancreatic Polypeptide (PP) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Mouse Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Mouse Pancreatic Polypeptide (PP) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Pancreatic Polypeptide (PP) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Rat Pancreatic Polypeptide (PP) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species.
Description: Quantitativesandwich ELISA kit for measuring Human Pancreatic Polypeptide, PP in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Description: Quantitativesandwich ELISA kit for measuring Human Pancreatic Polypeptide, PP in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human PPY / Pancreatic Polypeptide (Internal). This antibody is tested and proven to work in the following applications:
Description: A competitive ELISA for quantitative measurement of Guinea pig Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Guinea pig Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive ELISA for quantitative measurement of Guinea pig Pancreatic Polypeptide in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Pancreatic Polypeptide (PP) in samples from serum, plasma or other biological fluids.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Human Pancreatic Polypeptide (PP) in samples from serum, plasma or other biological fluids.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse Pancreatic Polypeptide (PP) in samples from serum, plasma or other biological fluids.
Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse Pancreatic Polypeptide (PP) in samples from serum, plasma or other biological fluids.
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