July 17, 2024

Expertise From Incorporating a Related Genetic Illness All through a Course

In Vitro Assays to Examine PD-1 Biology in Human T Cells

Our understanding of programmed cell demise 1 (PD-1) biology is proscribed as a result of technical difficulties in establishing reproducible, but easy, in vitro assays to check PD-1 signaling in main human T cells. The protocols on this article had been refined to check the implications of PD-1 ligation on short-term T cell signaling, long-term T cell perform, and the structural penalties of PD-1 ligation with PD-1 ligands. 

  • Fundamental Protocol 1 addresses the necessity for a sturdy and reproducible short-term assay to look at the signaling cascade triggered by PD-1. We describe a phospho stream cytometry technique to find out how PD-1 ligation alters the extent of CD3ζ phosphorylation on Tyr142 , which might be simply utilized to different proximal signaling proteins.

  • Fundamental Protocol 2 describes a plate-bound assay that’s helpful to look at the long-term penalties of PD-1 ligation comparable to cytokine manufacturing and T cell proliferation.
  • Complementary to that, Fundamental Protocol Three describes an in vitro superantigen-based assay to judge T cell responses to therapeutic brokers focusing on the PD-1/PD-L axis, in addition to immune synapse formation within the presence of PD-1 engagement. Lastly, in Fundamental Protocol Four we define a tetramer-based technique helpful to interrogate the standard of PD-1/PD-L interactions.
  • These protocols might be simply tailored for mouse research and different inhibitory receptors. They supply a beneficial useful resource to analyze PD-1 signaling in T cells and the purposeful penalties of varied PD-1-based therapeutics on T cell responses.
  • © 2020 Wiley Periodicals LLC. Fundamental Protocol 1: PD-1 crosslinking assay to find out CD3ζ phosphorylation in main human T cells Fundamental Protocol 2: Plate-based ligand binding assay to check PD-1 perform in human T cells Help Protocol 1: T cell proliferation assay within the presence of PD-1 ligation Fundamental Protocol 3: In vitro APC/T cell co-culture system to judge therapeutic interventions focusing on the PD-1/PD-L1 axis Help Protocol 2: Microscopy-based strategy to judge the implications of PD-1 ligation on immune synapse formation Fundamental Protocol 4: Tetramer-based strategy to check PD-1/PD-L1 interactions.

Tailor-made Educating for Specialised (Para-)medical College students – Expertise From Incorporating a Related Genetic Illness All through a Course of Molecular Cell Biology

Worldwide, a compulsory course in Molecular Cell Biology is commonly a part of the (para-) medical curricula. Pupil audiences are commonly not receptive to such comparatively theoretical programs and academics typically battle to convey the mandatory data.

Right here, constructive expertise is shared on rigorously embedding a genetic illness that severely impacts the motion equipment, fibrodysplasia ossificans progressiva (FOP), in all points of a course for a global group of Analysis Grasp Human Motion Sciences college students. 

Varied molecular cell organic points of FOP had been systematically carried out within the course, protecting genetics, the biochemical penalties of the mutation, signaling pathways that have an effect on bone formation and lectures on methods to clone the mutation or treatment the mutation. College students had been invited to critically take into consideration methods to use the theories discovered within the course to investigate a analysis paper.

Through the sensible a part of the course, college students assisted in novel, innovative analysis on FOP affected person derived or management cells. Analysis findings had been reported in a analysis paper format. By constructing a Molecular Cell Biology course round an interesting illness, we managed to extend the overall motivation of the scholars for the course as mirrored in two particular questions of the course evaluations (p < 0.05).

It convincingly taught the relevance of a course of Molecular Cell Biology to college students with a main background in biomechanics and physiotherapy for his or her paramedical skilled life. This strategy of embedding an audience-tailored human illness with a recognized genetic trigger right into a course might be carried out to many medical curriculum associated programs and can improve college students’ notion of the relevance of a course. 

HK1 Rabbit pAb

A1054-50ul 50 ul
EUR 267.6

HK1 Rabbit pAb

A0546-100ul 100 ul
EUR 369.6

HK1 Rabbit pAb

A0546-200ul 200 ul
EUR 550.8

HK1 Rabbit pAb

A0546-20ul 20 ul Ask for price

HK1 Rabbit pAb

A0546-50ul 50 ul Ask for price

HK1 Rabbit pAb

E2501054 100ul
EUR 225
Description: Available in various conjugation types.

HK1 Rabbit pAb

MBS8544202-01mL 0.1mL
EUR 305

HK1 Rabbit pAb

MBS8544202-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 Rabbit pAb

MBS8544202-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 Rabbit pAb

MBS8544202-01mLAF610 0.1mL(AF610)
EUR 565

HK1 Rabbit pAb

MBS8544202-01mLAF635 0.1mL(AF635)
EUR 565

HK1 Rabbit mAb

A20796 20μL
EUR 226.72

HK1 Rabbit mAb

A10886 50μL
EUR 382.59

HK1 Rabbit pAb

A0546 200μL
EUR 173.58

Rabbit Polyclonal Anti-HK1 Antibody

TA349618 100 µl Ask for price

Rabbit Polyclonal Anti-HK1 Antibody

TA343098 100 µl Ask for price

Rabbit Polyclonal Anti-HK1 Antibody

TA343099 100 µl Ask for price

HK1/HK2 Rabbit pAb

E2121853 100ul
EUR 225
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Hexokinase 1 (HK1) (N-term) rabbit polyclonal antibody, Purified

AP15128PU-N 400 µl Ask for price

Hexokinase 1 (HK1) (C-term) rabbit polyclonal antibody, Purified

AP15129PU-N 400 µl Ask for price

Rabbit HK1 ELISA Kit

ERTH0075 96Tests
EUR 625.2

Rabbit polyclonal anti-HK1 (HXK1) antibody

TA311675 100 µl Ask for price

Rabbit anti-Oryza sativa subsp. indica (Rice) HK1 Polyclonal Antibody

MBS7147231-INQUIRE INQUIRE Ask for price

Rabbit anti-Oryza sativa subsp. japonica (Rice) HK1 Polyclonal Antibody

MBS7146822-INQUIRE INQUIRE Ask for price

HK1 (C-term) Rabbit pAb

E2616638 100ul
EUR 225
Description: Available in various conjugation types.

HK1 (C-Term) Rabbit pAb

MBS8555239-01mL 0.1mL
EUR 305

HK1 (C-Term) Rabbit pAb

MBS8555239-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 (C-Term) Rabbit pAb

MBS8555239-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 (C-Term) Rabbit pAb

MBS8555239-01mLAF610 0.1mL(AF610)
EUR 565

HK1 (C-Term) Rabbit pAb

MBS8555239-01mLAF635 0.1mL(AF635)
EUR 565

HK1 antibody

10R-2226 100 ul
EUR 468
Description: Mouse monoclonal HK1 antibody

HK1 antibody

10R-2231 100 ul
EUR 468
Description: Mouse monoclonal HK1 antibody

HK1 Antibody

32133 100ul
EUR 439

HK1 Antibody

32133-100ul 100ul
EUR 302.4

HK1 Antibody

E10-30084 100μg/100μl
EUR 225
Description: Available in various conjugation types.

HK1 Antibody

E10-30089 100μg/100μl
EUR 225
Description: Available in various conjugation types.

HK1 Antibody

E19-6199 100μg/100μl
EUR 225
Description: Available in various conjugation types.

HK1 antibody

E39-10353 100ug/100ul
EUR 225
Description: Available in various conjugation types.

HK1 Antibody

E91054 100ul
EUR 255
Description: Available in various conjugation types.

HK1 Antibody

E306200 100ug/200ul
EUR 275
Description: Available in various conjugation types.

HK1 antibody

70R-17747 50 ul
EUR 289
Description: Rabbit polyclonal HK1 antibody

HK1 antibody

70R-10229 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal HK1 antibody

HK1 antibody

70R-10230 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal HK1 antibody

HK1 antibody

70R-35878 100 ug
EUR 420
Description: Rabbit polyclonal HK1 antibody

HK1 Antibody

1-CSB-PA010468GA01HU
  • Ask for price
  • Ask for price
  • 150ul
  • 50ul
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

HK1 Antibody

1-CSB-PA010468HA01HU
  • Ask for price
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  • 100ug
  • 50ug
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

HK1 Antibody

1-CSB-PA010468LA01HU
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  • 100ug
  • 50ug
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA

HK1 Antibody

1-CSB-PA002994
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  • 100ug
  • 50ug
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

HK1 Antibody

1-CSB-PA643791
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  • 100ul
  • 50ul
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

HK1 Antibody

CSB-PA230660- each
EUR 402
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

HK1 Antibody

CSB-PA230660-100ul 100ul
EUR 379.2
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:3000

HK1 Antibody

1-CSB-PA093794
  • Ask for price
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  • 100ul
  • 50ul
Description: A polyclonal antibody against HK1. Recognizes HK1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:5000, IHC:1:50-1:200

HK1 Antibody

ABD6199 100ug
EUR 325

HK1 Antibody

GWB-MW146B 50ug Ask for price

HK1 Antibody

GWB-MW147C 50ug Ask for price

HK1 antibody

BF0126 100ug
EUR 355

HK1 Antibody

MBS7130762-01mL 0.1mL
EUR 270

HK1 Antibody

MBS7130762-5x01mL 5x0.1mL
EUR 1200

HK1 Antibody

MBS7124984-005mL 0.05mL
EUR 190

HK1 Antibody

MBS7124984-01mL 0.1mL
EUR 270

HK1 Antibody

MBS7124984-5x01mL 5x0.1mL
EUR 1205

HK1 Antibody

MBS7124985-005mL 0.05mL
EUR 190

HK1 Antibody

MBS7124985-01mL 0.1mL
EUR 270

HK1 Antibody

MBS7124985-5x01mL 5x0.1mL
EUR 1205

HK1 Antibody

MBS7122100-005mg 0.05mg
EUR 150

HK1 Antibody

MBS7122100-01mg 0.1mg
EUR 190

HK1 Antibody

MBS7122100-5x01mg 5x0.1mg
EUR 845

HK1 Antibody

MBS9402040-005mL 0.05mL
EUR 300

HK1 Antibody

MBS9402040-01mL 0.1mL
EUR 390

HK1 Antibody

MBS9402040-5x01mL 5x0.1mL
EUR 1610

HK1 Antibody

MBS858412-01mg 0.1mg
EUR 345

HK1 Antibody

MBS858412-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 Antibody

MBS858412-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 Antibody

MBS858412-01mLAF610 0.1mL(AF610)
EUR 565

HK1 Antibody

MBS858412-01mLAF635 0.1mL(AF635)
EUR 565

HK1 Antibody

MBS8505483-01mL 0.1mL
EUR 325

HK1 Antibody

MBS8505483-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 Antibody

MBS8505483-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 Antibody

MBS8505483-01mLAF610 0.1mL(AF610)
EUR 565

HK1 Antibody

MBS8505483-01mLAF635 0.1mL(AF635)
EUR 565

HK1 Antibody

MBS850604-01mg 0.1mg
EUR 305

HK1 Antibody

MBS850604-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 Antibody

MBS850604-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 Antibody

MBS850604-01mLAF610 0.1mL(AF610)
EUR 565

HK1 Antibody

MBS850604-01mLAF635 0.1mL(AF635)
EUR 565

HK1 Antibody

MBS850834-01mg 0.1mg
EUR 305

HK1 Antibody

MBS850834-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 Antibody

MBS850834-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 Antibody

MBS850834-01mLAF610 0.1mL(AF610)
EUR 565

HK1 Antibody

MBS850834-01mLAF635 0.1mL(AF635)
EUR 565

HK1 Antibody

MBS8516116-01mg 0.1mg
EUR 305

HK1 Antibody

MBS8516116-01mLAF405L 0.1mL(AF405L)
EUR 465

HK1 Antibody

MBS8516116-01mLAF405S 0.1mL(AF405S)
EUR 465

HK1 Antibody

MBS8516116-01mLAF610 0.1mL(AF610)
EUR 465

HK1 Antibody

MBS8516116-01mLAF635 0.1mL(AF635)
EUR 465

HK1 Antibody

MBS2521657-006mL 0.06mL
EUR 190

HK1 Antibody

MBS2521657-012mL 0.12mL
EUR 265

HK1 Antibody

MBS2521657-02mL 0.2mL
EUR 415

HK1 Antibody

MBS2521657-5x02mL 5x0.2mL
EUR 1835

HK1 antibody

MBS533821-01mL 0.1mL
EUR 810

HK1 antibody

MBS533821-5x01mL 5x0.1mL
EUR 3505

HK1 Antibody

MBS5313351-01mg 0.1mg
EUR 635

HK1 Antibody

MBS5313351-5x01mg 5x0.1mg
EUR 2705

HK1 Antibody

MBS9606858-01mL 0.1mL
EUR 260

HK1 Antibody

MBS9606858-02mL 0.2mL
EUR 305

HK1 Antibody

MBS9606858-5x02mL 5x0.2mL
EUR 1220

HK1 Antibody

BF0126-100ul 100ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA

HK1 Antibody

BF0126-200ul 200ul Ask for price
Description: WB,IHC,IF/ICC,ELISA

HK1 Antibody

BF0126-50ul 50ul
EUR 150
Description: WB,IHC,IF/ICC,ELISA

[KO Validated] HK1 Rabbit mAb

A0533 20 μL
EUR 213.2
Description: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Pumilio 2 (Q8TB72).

[KO Validated] HK1 Rabbit mAb

A0533-200ul 200 ul
EUR 823.2

[KO Validated] HK1 Rabbit mAb

A0533-20ul 20 ul
EUR 265.2

[KO Validated] HK1 Rabbit mAb

A23524 500μL
EUR 323.7
Description: A synthetic peptide corresponding to a sequence within amino acids 100-209 of human LIN28A (NP_078950.1).

[KO Validated] HK1 Rabbit pAb

A1054 1000μL
EUR 343.62

Rabbit Anti-HK1 monoclonal antibody, clone TU58-16

DCABH-4091 100 ul
EUR 932.4

HK1/HK2 antibody

31975 100ul
EUR 319

HK1/HK2 antibody

31975-100ul 100ul
EUR 302.4

HK1/HK2 antibody

31975-50ul 50ul
EUR 224.4

HK1/HK2 Antibody

MBS9434806-01mL 0.1mL
EUR 305

HK1/HK2 Antibody

MBS9434806-5x01mL 5x0.1mL
EUR 1230

anti- HK1 antibody

FNab03893 100µg
EUR 606.3
Description: Antibody raised against HK1

HK1 (Hexokinase) (N-term) Rabbit pAb

E2620331 100ul
EUR 225
Description: Available in various conjugation types.

HK1 (Hexokinase) (N-Term) Rabbit pAb

MBS8558586-01mL 0.1mL
EUR 305

HK1 (Hexokinase) (N-Term) Rabbit pAb

MBS8558586-01mLAF405L 0.1mL(AF405L)
EUR 565

HK1 (Hexokinase) (N-Term) Rabbit pAb

MBS8558586-01mLAF405S 0.1mL(AF405S)
EUR 565

HK1 (Hexokinase) (N-Term) Rabbit pAb

MBS8558586-01mLAF610 0.1mL(AF610)
EUR 565

HK1 (Hexokinase) (N-Term) Rabbit pAb

MBS8558586-01mLAF635 0.1mL(AF635)
EUR 565

Rabbit Hexokinase-1 (HK1) ELISA Kit

MBS2803220-10x96StripWells 10x96-Strip-Wells
EUR 6255

Rabbit Hexokinase-1 (HK1) ELISA Kit

MBS2803220-48StripWells 48-Strip-Wells
EUR 445

Rabbit Hexokinase-1 (HK1) ELISA Kit

MBS2803220-5x96StripWells 5x96-Strip-Wells
EUR 3290

Rabbit Hexokinase-1 (HK1) ELISA Kit

MBS2803220-96StripWells 96-Strip-Wells
EUR 730

Rabbit Anti Human HK1 Monoclonal Clone EOF-8

IRBAHUHK1EOF8C100UL each
EUR 496
Description: Rabbit Anti Human HK1 Monoclonal Clone EOF-8

HK1 Antibody (C-term)

MBS9206449-008mL 0.08mL
EUR 210

HK1 Antibody (C-term)

MBS9206449-04mL 0.4mL
EUR 430

HK1 Antibody (C-term)

MBS9206449-5x04mL 5x0.4mL
EUR 1910

Hexokinase 1 (HK1) Antibody

20-abx109871
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx109872
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx112999
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Hexokinase 1 (HK1) Antibody

20-abx100798
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx100799
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx100800
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx100801
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx100802
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx100803
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx130172
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

20-abx121415
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  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Hexokinase 1 (HK1) Antibody

20-abx125339
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  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 50 ul

Hexokinase 1 (HK1) Antibody

20-abx126932
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  • Ask for price
  • 100 ul
  • 200 ul

Hexokinase 1 (HK1) Antibody

abx036294-100ug 100 ug
EUR 469.2

Hexokinase 1 (HK1) Antibody

abx033903-400ul 400 ul
EUR 627.6

Hexokinase 1 (HK1) Antibody

abx033903-80l 80 µl
EUR 343.2

Hexokinase 1 (HK1) Antibody

abx033904-400ul 400 ul
EUR 627.6

Hexokinase 1 (HK1) Antibody

abx033904-80l 80 µl
EUR 343.2

Hexokinase 1 (HK1) Antibody

abx015885-100ul 100 ul
EUR 493.2

Hexokinase 1 (HK1) Antibody

abx010915-100ul 100 ul
EUR 493.2

Hexokinase 1 (HK1) Antibody

20-abx000977
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  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Hexokinase 1 (HK1) Antibody

abx233847-100ug 100 ug
EUR 577.2

Hexokinase 1 (HK1) Antibody

abx233893-100ug 100 ug
EUR 577.2

Hexokinase 1 (HK1) Antibody

20-abx214585
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  • Ask for price
  • 100 ul
  • 50 ul

Hexokinase 1 (HK1) Antibody

20-abx214586
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  • Ask for price
  • 100 ul
  • 50 ul

Hexokinase 1 (HK1) Antibody

20-abx172800
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  • Ask for price
  • 1 mg
  • 200 ug

Hexokinase 1 (HK1) Antibody

abx332645-100ul 100 ul
EUR 510

Hexokinase 1 (HK1) Antibody

20-abx329456
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Hexokinase 1 (HK1) Antibody

abx159534-100ul 100 ul
EUR 560.4

HK1 Antibody / Hexokinase 1

F54454-0.08ML 0.08 ml
EUR 140.25
Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

HK1 Antibody / Hexokinase 1

F54454-0.4ML 0.4 ml
EUR 322.15
Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. The hexokinase gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of the hexokinase gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. HK1 encodes the ubiquitously expressed isoform. Its 5' end includes an exon which is unique to this transcript and which encodes a distinct N-terminus that contains the porin binding domain (PBD). The porin binding domain mediates association with the mitochondrial membrane.

HK1 Antibody / Hexokinase 1

RQ5659 100 ug
EUR 356.15
Description: Hexokinase-1 (HK1) is an enzyme that in humans is encoded by the HK1 gene on chromosome 10. It is mapped to 10q22.1. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific.
ucidevcell
ucidevcell

Focusing on A number of Myeloma by way of the Biology of Lengthy-Lived Plasma Cells

A number of myeloma (MM) is a hematological malignancy of terminally differentiated bone marrow (BM) resident B lymphocytes referred to as plasma cells (PC). PC that reside within the bone marrow embrace a definite inhabitants of long-lived plasma cells (LLPC) which have the capability to stay for very lengthy intervals of time (a long time within the human inhabitants).

LLPC biology is essential for understanding MM illness induction and development as a result of MM shares lots of the similar extrinsic and intrinsic survival applications as LLPC. Extrinsic survival alerts required for LLPC survival embrace soluble elements and mobile companions within the bone marrow microenvironment. Intrinsic applications that improve mobile constancy are additionally required for LLPC survival together with elevated autophagy, metabolic health, the unfolded protein response (UPR), and enhanced responsiveness to endoplasmic reticulum (ER) stress.

Focusing on LLPC cell survival mechanisms have led to straightforward of care therapies for MM together with proteasome inhibition (Bortezomib), steroids (Dexamethasone), and immunomodulatory medication (Lenalidomide). MM sufferers that relapse typically accomplish that by circumventing LLPC survival pathways focused by therapy. Understanding the mechanisms by which LLPC are capable of survive can enable us perception into the therapy of MM, which permits for the enhancement of therapeutic methods in MM each at analysis and upon affected person relapse.   

Ethylene thiourea

MBS5756335-100mg 100mg
EUR 190

Ethylene thiourea

MBS5756335-200mg 200mg
EUR 220

Ethylene thiourea

MBS5756335-500mg 500mg
EUR 285

Ethylene thiourea

MBS5756335-5x500mg 5x500mg
EUR 1125

Thiourea

09861-15 500G
EUR 49

Thiourea

33811-15 500G
EUR 14

Thiourea

33812-05 500G
EUR 16.1

Thiourea

33812-92 25G
EUR 9.45

Thiourea

42000094-1 25 g
EUR 12.21

Thiourea

42000094-2 100 g
EUR 34.4

Thiourea

42000094-3 1 kg
EUR 63.78

Thiourea

GE8159 100g
EUR 177.36

Thiourea

GE8159-1 1
EUR 55.4

Thiourea

GE8159-100 100
EUR 15.9

Thiourea

GE8159-100G 100 g
EUR 55.2

Thiourea

GE8159-1KG 1 kg
EUR 103.2

Thiourea

GE8159-5 5
EUR 193.7

Thiourea

GE8159-500 500
EUR 35.5

Thiourea

GE8159-500G 500 g
EUR 79.2

Thiourea

GE8159-5KG 5 kg
EUR 270

Thiourea

TB1943 500g
EUR 80.88

THIOUREA

T7982 100G
EUR 88.24

Thiourea

T375450 10g
EUR 92
Description: 62-56-6

Thiourea-13C

T375454 250mg
EUR 198
Description: 113899-66-4

Ethylene Di(thiotosylate)

E937400 100mg
EUR 64

Thiourea 100gm - EACH

RPN6301 EACH
EUR 141.75

Thiourea-13C,15N2

T375452 250mg
EUR 196
Description: 285977-83-5

Triallyl Thiourea

T17495 5G
EUR 372.2

Thiourea pure, 98%

88196 500 Gms
EUR 6.84
Description: Part A

Thiourea, Hi-LR™

GRM1431-500G 1 unit
EUR 11.87
Description: Thiourea, Hi-LR™

2-Methylamino Thiourea

abx187868-100g 100 g
EUR 360

1,2-Ethylene Glycol (Ethylene Glycol)

E890140 1ml
EUR 132
Description: 107-21-1

Diphenyl Thiourea pure, 98%

52196 100 Gms
EUR 6.15
Description: Part B

1-(3-Bromophenyl)thiourea

B698725 100mg
EUR 75
Description: 21327-14-0

1,3-Propylene-d6 Thiourea

T311372 10mg
EUR 75
Description: 1219802-05-7

Thiourea, Hi-AR™/ACS

GRM611-100G 1 unit
EUR 6.93
Description: Thiourea, Hi-AR™/ACS

Thiourea, Hi-AR™/ACS

GRM611-500G 1 unit
EUR 19.69
Description: Thiourea, Hi-AR™/ACS

a-(4-Chlorophenyl)thiourea

MBS6061329-250mg 250(mg
EUR 485

a-(4-Chlorophenyl)thiourea

MBS6061329-5x250mg 5x250mg
EUR 2025

N-(2,3-Dimethylphenyl)-thiourea

D477330 2.5g
EUR 1200
Description: 55752-58-4

N-Boc-n'-methyl thiourea

20-abx185514
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  • 250 mg

N,N'-(1,2-Propylene)thiourea

P836800 2.5g
EUR 224
Description: 2122-19-2

Thiourea 99% ACS Reagent Grade

T11935 50G
EUR 200.25

[4-(Trifluoromethyl)phenyl] Thiourea

T796425 100mg
EUR 121

Ethylene-vinyl acetate, 20% ethylene, fine powder

24763-1 1kg
EUR 315
Description: 24937-78-8

Ethylene-vinyl acetate, 20% ethylene, fine powder

24763-50 50g
EUR 48
Description: 24937-78-8

Thiourea Superior extrapure AR, 99%

16994 100 Gms
EUR 4.17
Description: Part A

Extraction Buffer for 2D Gel with Diluent, 50ml Urea, Thiourea and CHAPS

PL039 50ml
EUR 87.14

cDNA Synthesis SuperMix for qPCR

20-abx09801920ulSystems
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  • 100 rxns ×20 ul Systems
  • 50 rxns × 20 ul Systems

cDNA Synthesis SuperMix for qPCR

abx098019-100l 100 µl
EUR 825

cDNA Synthesis SuperMix for qPCR

abx098019-1ml 1 ml
EUR 2387.5

cDNA Synthesis SuperMix for qPCR

abx098019-200l 200 µl
EUR 1000

N,N'-(1,2-Propylene)thiourea-d6

P836802 10mg
EUR 257

5-Fluoro-2-methylphenyl Thiourea

F598223 100mg
EUR 63
Description: 16822-86-9

1-(2-Tetrahydrofurfuryl)-2-thiourea

T293790 5g
EUR 1200
Description: 66892-25-9

5-Chloro-2-methoxyphenyl thiourea

C14005 5G
EUR 173.58

Trifluoroacetic acid, Ultrapure for synthesis

GK2000 100ml
EUR 239.02

Trifluoroacetic acid, Ultrapure for synthesis

GK2000-1 1
EUR 261

Trifluoroacetic acid, Ultrapure for synthesis

GK2000-100 100
EUR 39.4

Trifluoroacetic acid, Ultrapure for synthesis

GK2000-100ML 100 ml
EUR 84

Trifluoroacetic acid, Ultrapure for synthesis

GK2000-1L 1 l
EUR 351.6

Ethylene Glycol

15208-24 20L
EUR 108.5

Ethylene Glycol

15208-53 3L
EUR 40.6

Ethylene Glycol

15208-95 500ML
EUR 8.75

Ethylene Glycol

15209-85 500ML
EUR 10.15

Ethylene Glycol

15212-25 500ML
EUR 13.3

Ethylene Glycol

15225-65 500ML
EUR 12.95

Ethylene Glycol

11680-15 500ML
EUR 34.3

Ethylene Glycol

40570004-1 1 L
EUR 30.14

Ethylene Glycol

40570004-2 4 L
EUR 117.23

Ethylene glycol

20-abx184690
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  • 100 g
  • 1 kg
  • 25 g
  • 500 g
  • 5 g

Ethylene glycol

ED0199 250ml
EUR 70.44

Ethylene glycol

GK7641 100ml
EUR 76.04

Ethylene glycol

GK7641-1 1
EUR 23.8

Ethylene glycol

GK7641-100 100
EUR 9.8

Ethylene glycol

GK7641-100ML 100 ml
EUR 45.6

Ethylene glycol

GK7641-1L 1 l
EUR 64.8

Ethylene glycol

GK7641-5 5
EUR 83.1

Ethylene glycol

GK7641-500 500
EUR 15.7

Ethylene glycol

GK7641-500ML 500 ml
EUR 52.8

Ethylene glycol

GK7641-5L 5 l
EUR 136.8

Ethylene Diamine

E917695 1l
EUR 150
Description: 107-15-3

[(Dimethylamino)methylene](triphenylmethyl)-thiourea

D461055 100mg
EUR 1608

Acetonitrile (ACN) for DNA synthesis, 99.9%

62076 1000 ml
EUR 15.26
Description: Part A

Ethylene Carbonate

15012-32 25G
EUR 8.4

Ethylene Carbonate

15012-45 500G
EUR 19.25

N-(8-Bromo-6-quinoxalinyl)thiourea

B686965 2.5g
EUR 3000
Description: 1217439-05-8

Extraction Buffer for 2D Gel with Diluent, 50ml Urea, Thiourea, CHAPS and NDSB 201

PL042 50ml
EUR 110.11

1-​(4-​(Trifluoromethoxy)​phenyl)​-​2-​thiourea

T791590 1g
EUR 57
Description: 142229-74-1

Extraction Buffer for 2D Gel with Diluent, 50ml Urea, Thiourea, CHAPS and ASB-16

PL040 50ml
EUR 138.3

Ethylene Bromohydrin

15029-32 25G
EUR 23.1

3-Amino-1-(pyridin-3-yl)thiourea

A630383 5g
EUR 1200
Description: 34955-25-4

Extraction Buffer for 2D Gel with Diluent, 50ml Urea, Thiourea, CHAPS and SB 3-10

PL041 50ml
EUR 110.11

1-(1-Naphthyl)-2-thiourea 97%_x000D__x000D_

N03285 10G
EUR 315.72

Ethylene oxide 99%

E09560 227G
EUR 5834.13

1,1-Dimethyl-3-(meta-tolyl)-2-thiourea

D462313 500mg
EUR 800
Description: 21540-35-2

Ethylene glycol 99%

E08970 1KG
EUR 230.26

Ethylene Urea-d4

E917782 100mg
EUR 178
Description: 62740-68-5

Ethylene Oxide - 1ML

S-1960 1ML
EUR 82.35

Ethylene Urea-d4

MBS6081653-10mg 10(mg
EUR 530

Ethylene Urea-d4

MBS6081653-5x10mg 5x10mg
EUR 2240

Ethylene sulfide 97%

E09590 25G
EUR 401.7

Ethylene glycol - 1ML

S-1952 1ML
EUR 51.3

DCCD (Redistilled for Solid-Phase Synthesis)

MBS406597-100g 100g
EUR 200

DCCD (Redistilled for Solid-Phase Synthesis)

MBS406597-500g 500g
EUR 515

DCCD (Redistilled for Solid-Phase Synthesis)

MBS406597-5x100g 5x100g
EUR 855

DCCD (Redistilled for Solid-Phase Synthesis)

MBS406597-5x500g 5x500g
EUR 2265

Ethylene Glycol-d6

E939175 10mg
EUR 64
Description: 15054-86-1

Ethylene-d4 Glycol

E917522 100mg
EUR 68
Description: 2219-51-4

Ethylene carbonate 99%

E08280 1KG
EUR 147.9

Ethylene-d4 Diamine

E917697 250mg
EUR 173
Description: 37164-19-5

Ethylene Dimethanesulfonate

E940650 250mg
EUR 69
Description: 4672-49-5

Ethylene dimethanesulfonate

T13689-10mg 10mg Ask for price
Description: Ethylene dimethanesulfonate

Ethylene dimethanesulfonate

T13689-1g 1g Ask for price
Description: Ethylene dimethanesulfonate

Ethylene dimethanesulfonate

T13689-1mg 1mg Ask for price
Description: Ethylene dimethanesulfonate

Ethylene dimethanesulfonate

T13689-50mg 50mg Ask for price
Description: Ethylene dimethanesulfonate

Ethylene dimethanesulfonate

T13689-5mg 5mg Ask for price
Description: Ethylene dimethanesulfonate

Ethylene dimethanesulfonate

MBS5768053-100mg 100mg
EUR 200

Ethylene dimethanesulfonate

MBS5768053-25mg 25mg
EUR 145

Ethylene dimethanesulfonate

MBS5768053-50mg 50mg
EUR 165

Ethylene dimethanesulfonate

HY-129524 100 mg
EUR 91.99
Description: Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs[1].

cDNA Synthesis SuperMix for qPCR (GC-rich)

abx098024-50rxns20ulSystems 50 rxns × 20 ul Systems
EUR 861.6

cDNA Synthesis SuperMix for qPCR (GC-rich)

abx098024-100l 100 µl
EUR 1025

cDNA Synthesis SuperMix for qPCR (GC-rich)

abx098024-1ml 1 ml Ask for price

cDNA Synthesis SuperMix for qPCR (GC-rich)

abx098024-200l 200 µl Ask for price

Ethylene brassylate 97%

E08250 10G
EUR 173.61

Solabegron Ethylene D4

S676507 25mg
EUR 15000
Description: 1250986-04-9

Ethylene-beta-ionol

MBS6016726-50mg 50(mg
EUR 610

Ethylene-beta-ionol

MBS6016726-5x50mg 5x50mg
EUR 2600

3-tert-Butyl-1-(propan-2-yl)thiourea

B490823 750mg
EUR 800
Description: 52599-24-3

Ethylene bisacetamide 95%

E08000 10G
EUR 252.66

Ethylene chlorohydrin 99%

E08340 1KG
EUR 591.59

N,N'-Bis(2-aminoethyl)thiourea Dihydrochloride

B402220 100mg
EUR 1384
Description: 1639405-29-0

Ethylene glycol diformate

E09117 10G
EUR 470.77

Ethylene Glycol Dicaprate

E917474 250mg
EUR 489
Description: 627-85-0

Ethylene Glycol Dilaurate

E917476 100mg
EUR 224

First-Strand cDNA Synthesis SuperMix for PCR

abx098018-50rxns20ulSystems 50 rxns × 20 ul Systems
EUR 693.6

First-Strand cDNA Synthesis SuperMix for PCR

abx098018-100l 100 µl
EUR 850

First-Strand cDNA Synthesis SuperMix for PCR

abx098018-1ml 1 ml Ask for price

First-Strand cDNA Synthesis SuperMix for PCR

abx098018-200l 200 µl Ask for price

18:1 Ethylene Glycol

HY-143689 Get quote Ask for price
Description: 18:1 Ethylene Glycol is a liposome used to deliver agents.

Ethylene glycol distearate

E09180 25G
EUR 143.3

Ethylene bis-Palmitamide

E451825 100mg
EUR 184
Description: 5518-18-3

Ethylene Glycol Distearate

E917570 500mg
EUR 800
Description: 627-83-8

IG® sgRNA Synthesis Kit for Cas9 Nuclease

3203 10RNS(20µlRXNVolume)
EUR 175.2

IG® sgRNA Synthesis Kit for Cas9 Nuclease

3206 10RNS(100µlRXNVolume)
EUR 895.2

Ethylene Glycol Dimyristate

E917560 500mg
EUR 800
Description: 627-84-9

Ethylene Glycol Dipalmitate

E917565 500mg
EUR 800
Description: 624-03-3

Ethylene Glycol Monolaurate

E917585 250mg
EUR 489
Description: 4219-48-1

Poly(ethylene terephthalate)

GRM8819-500G 1 unit
EUR 172.1
Description: Poly(ethylene terephthalate)

Uni Cell to cDNA Synthesis SuperMix for qPCR

abx098860-100l 100 µl
EUR 1012.5

Uni Cell to cDNA Synthesis SuperMix for qPCR

abx098860-1ml 1 ml Ask for price

Uni Cell to cDNA Synthesis SuperMix for qPCR

abx098860-200l 200 µl Ask for price

Poly(ethylene glycol) 10,000

RM10793-500G 1 unit
EUR 23.93
Description: Poly(ethylene glycol) 10,000

Poly(ethylene Glycol) (~2000)

P688350 100mg
EUR 92
Description: 25322-68-3

Poly(ethylene Glycol) ~200

P688355 10g
EUR 158

Poly(ethylene Glycol) ~1000

P688360 10g
EUR 153
Description: 25322-68-3

Poly(ethylene Glycol) ~600

P688365 100g
EUR 127
Description: 25322-68-3

Poly(ethylene Glycol) ~400

P688370 10g
EUR 155
Description: 25322-68-3

Poly(ethylene Glycol) ~20000

P688373 100g
EUR 63
Description: 25322-68-3

Poly(ethylene Glycol) ~4000

P688374 100mg
EUR 51
Description: 25322-68-3

Poly(ethylene Glycol) ~6000

P688375 100g
EUR 65
Description: 25322-68-3

Poly(ethylene Glycol) ~30,000

P688378 25g
EUR 86
Description: 25322-68-3

Poly(ethylene Glycol) ~40,000

P688379 1g
EUR 132
Description: 25322-68-3

Poly(ethylene Glycol) ~3000

P688455 100mg
EUR 85

Poly(ethylene Glycol) ~9000

P689110 100mg
EUR 92
Description: 25322-68-3

Foam-tipped swabs for assisted collection, ethylene oxide treated (100)

ISGFS-01/100 each
EUR 180.4

1,3-Bis(2,6-diisopropyl-4-phenoxyphenyl)thiourea

B591975 100mg
EUR 1800

Ethylene glycol monostearate

E09375 100G
EUR 145

Ethylene trithiocarbonate 96%

E15500 25G
EUR 555.73

Ethylene Glycol Monostearate

E917480 100mg
EUR 136
Description: 111-60-4

Ethylene Gycol Monomyristate

E917580 500mg
EUR 800
Description: 22122-18-5

IG® sgRNA Synthesis Kit for Cas12a Nuclease

3303 10RNS(20µlRXNVolume)
EUR 191.2

IG® sgRNA Synthesis Kit for Cas12a Nuclease

3306 10RNS(100µlRXNVolume)
EUR 919.2

Ethylene Diamine pure, 99%

65428 500 ml
EUR 4.79
Description: Part A

N-(5-Fluoresceinyl)-N’-(2-cyclopamineethyl)thiourea

F530000 0.25mg
EUR 1173

Ethylene glycol diricinoleate

E09170 5G
EUR 113.97

Ethylene Glycol Monooctanoate

E917545 500mg
EUR 800
Description: 4219-47-0

Ethylene Glycol Monodecanoate

E917555 250mg
EUR 489
Description: 16179-41-2

Ethylene Glycol Monopalmitate

E917575 50mg
EUR 138
Description: 4219-49-2

mono-(BOC)-ethylene diamine

20-abx184234
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  • 100 g
  • 25 g
  • 500 g

Ethylene urea 97%_x000D__x000D_

E09640 25G
EUR 126.03

Ethylene glycol monosalicylate

E09370 25G
EUR 119.43

N-(5-Chloro-2,1,3-benzothiadiazol-4-yl)-thiourea

C364995 500mg
EUR 215
Description: 51323-05-8

N-(5-Chloro-2,1,3-benzothiadiazol-4-yl)-thiourea

MBS6089331-50mg 50(mg
EUR 575

N-(5-Chloro-2,1,3-benzothiadiazol-4-yl)-thiourea

MBS6089331-5x50mg 5x50mg
EUR 2440

1,2-Ethylene Glycol-13C2

E890142 100mg
EUR 322
Description: 104700-12-1

Ethylene glycol monoricinoleate

E09360 10G
EUR 1424.57

Ethylene glycol - 100 % v/v

CSS-183 100ml
EUR 75.2

Ethylene-13C2-diamine Dihydrochloride

E918354 2.5mg
EUR 81
Description: 77435-60-0

Ethylene glycol diethyl ether

RM10757-500ML 1 unit
EUR 67.75
Description: Ethylene glycol diethyl ether

Ethylene sulfite 98%_x000D__x000D_

E09600 25G
EUR 267.83

Ethylene-Beta-ionol-d3

E917542 100mg
EUR 201

EIN2 | Ethylene insensitive 2

AS12-1865 50 µg
EUR 302

EIN3 | Ethylene insensitive 3

AS19-4273 50 µl
EUR 302

Ethylene-beta-ionol-d3

MBS6103730-10mg 10(mg
EUR 610

Ethylene-beta-ionol-d3

MBS6103730-5x10mg 5x10mg
EUR 2600

Poly(ethylene oxide) [MW 100,000]

06104-500 500g
EUR 199
Description: 25322-68-3