March 30, 2023
ucidevcell

Dewetting: From Physics to the Biology of Intoxicated Cells

Dewetting: From Physics to the Biology of Intoxicated Cells

 Pathogenic micro organism colonize or disseminate into cells and tissues by inducing large-scale remodeling of host membranes. The bodily phenomena underpinning these big membrane extension and deformation are poorly understood. Invasive strategies of pathogens have been simply recently enriched by the define of a spectacular mode of opening of huge transendothelial cell macroaperture (TEM) tunnels correlated to the dissemination of EDIN-producing strains of Staphylococcus aureus by means of a hematogenous route or to the induction of gelatinous edema triggered by the edema toxin from Bacillus anthracis.

Remarkably, these extraordinarily dynamic tunnels shut shortly after they attain a maximal measurement. Opening and closure of TEMs in cells lasts for hours with out inducing endothelial cell demise. Multidisciplinary analysis have started to produce a broader perspective of every the molecular determinants controlling cytoskeleton group at newly curved membranes generated by the opening of TEMs and the bodily processes controlling the dynamics of these tunnels.

Proper right here we speak in regards to the analogy between the opening of TEM tunnels and the bodily concepts of dewetting, stemming from a parallel between membrane stress and ground stress. This analogy provides a broad framework to analysis biophysical constraints in cell membrane dynamics and their diversion by positive invasive microbial brokers

Present advances in myeloid-derived suppressor cell biology

 

In latest occasions, discovering out the place of myeloid-derived suppressor cells (MDSCs) in numerous pathological inflammatory conditions has become a very energetic evaluation area. Although the place of MDSCs in most cancers is relatively successfully established, their place in non-cancerous pathological conditions stays in its infancy resulting in rather a lot confusion. Our targets on this overview are to cope with some present advances in MDSC evaluation in order to lower such confusion and to produce an notion into their function inside the context of various illnesses.

The following issues is perhaps significantly centered upon:

(1) definition and characterization of MDSCs;

(2) whether or not or not all MDSC populations embrace immature cells;

(3) technical factors in MDSC isolation, estimation and characterization;

(4) the origin of MDSCs and their anatomical distribution in effectively being and sickness;

(5) mediators of MDSC development and accumulation;

(6) parts that determine the expansion of 1 MDSC inhabitants over the other;

(7) the Yin and Yang roles of MDSCs. Moreover, the capabilities of MDSCs is perhaps addressed all by the textual content material.

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ucidevcell

SFT2D3 Blocking Peptide

DF10009-BP 1mg
EUR 234

SEC22B Blocking Peptide

DF10010-BP 1mg
EUR 234

TMEM37 Blocking Peptide

DF10011-BP 1mg
EUR 234

CACNA1D Blocking Peptide

DF10012-BP 1mg
EUR 234

CACNA1E Blocking Peptide

DF10013-BP 1mg
EUR 234

CACNA1G Blocking Peptide

DF10014-BP 1mg
EUR 234

ZNHIT1 Blocking Peptide

DF10015-BP 1mg
EUR 234

ZFHX4 Blocking Peptide

DF10016-BP 1mg
EUR 234

ZNF295 Blocking Peptide

DF10017-BP 1mg
EUR 234

ZNF462 Blocking Peptide

DF10018-BP 1mg
EUR 234

ZNF600 Blocking Peptide

DF10019-BP 1mg
EUR 234

SLC30A2 Blocking Peptide

DF10020-BP 1mg
EUR 234

SLC39A10 Blocking Peptide

DF10021-BP 1mg
EUR 234

ZP2 Blocking Peptide

DF10022-BP 1mg
EUR 234

CD164L2 Blocking Peptide

DF10023-BP 1mg
EUR 234

CC50A Blocking Peptide

DF10024-BP 1mg
EUR 234

CCNI Blocking Peptide

DF10025-BP 1mg
EUR 234

CD2L5 Blocking Peptide

DF10026-BP 1mg
EUR 234

CD2L6 Blocking Peptide

DF10027-BP 1mg
EUR 234

CD2L7 Blocking Peptide

DF10028-BP 1mg
EUR 234

MAGA2 Blocking Peptide

DF10029-BP 1mg
EUR 234

MAGA3 Blocking Peptide

DF10030-BP 1mg
EUR 234

MAGA6 Blocking Peptide

DF10031-BP 1mg
EUR 234

MAGA8 Blocking Peptide

DF10032-BP 1mg
EUR 234

MAGAB Blocking Peptide

DF10033-BP 1mg
EUR 234

MAGAC Blocking Peptide

DF10034-BP 1mg
EUR 234

MAGB2 Blocking Peptide

DF10035-BP 1mg
EUR 234

MAGB3 Blocking Peptide

DF10036-BP 1mg
EUR 234

MAGB6 Blocking Peptide

DF10037-BP 1mg
EUR 234

MAGBA Blocking Peptide

DF10038-BP 1mg
EUR 234

MAGBI Blocking Peptide

DF10039-BP 1mg
EUR 234

MAGD2 Blocking Peptide

DF10040-BP 1mg
EUR 234

MAGE2 Blocking Peptide

DF10041-BP 1mg
EUR 234

MAGG1 Blocking Peptide

DF10042-BP 1mg
EUR 234

MAGH1 Blocking Peptide

DF10043-BP 1mg
EUR 234

KITH_HHV1E Blocking Peptide

DF10044-BP 1mg
EUR 234

CNBP Blocking Peptide

DF10045-BP 1mg
EUR 234

HEN2 Blocking Peptide

DF10046-BP 1mg
EUR 234

ATOH8 Blocking Peptide

DF10047-BP 1mg
EUR 234

AKAP4 Blocking Peptide

DF10048-BP 1mg
EUR 234

GFI1B Blocking Peptide

DF10049-BP 1mg
EUR 234

DMRTA1 Blocking Peptide

DF10050-BP 1mg
EUR 234

ZNF25 Blocking Peptide

DF10051-BP 1mg
EUR 234

TSH3 Blocking Peptide

DF10052-BP 1mg
EUR 234

LARP2 Blocking Peptide

DF10053-BP 1mg
EUR 234

UL97 Blocking Peptide

DF10054-BP 1mg
EUR 234

TRIM68 Blocking Peptide

DF10055-BP 1mg
EUR 234

TCF2 Blocking Peptide

DF10056-BP 1mg
EUR 234

ZNF839 Blocking Peptide

DF10057-BP 1mg
EUR 234

PTRF Blocking Peptide

DF10058-BP 1mg
EUR 234

CYFIP1 Blocking Peptide

DF10059-BP 1mg
EUR 234

TRMT11 Blocking Peptide

DF10060-BP 1mg
EUR 234

ZNF227 Blocking Peptide

DF10061-BP 1mg
EUR 234

DMRTC2 Blocking Peptide

DF10062-BP 1mg
EUR 234

YAF2 Blocking Peptide

DF10063-BP 1mg
EUR 234

ASPM Blocking Peptide

DF10064-BP 1mg
EUR 234

ZNF786 Blocking Peptide

DF10065-BP 1mg
EUR 234

C16orf44 Blocking Peptide

DF10066-BP 1mg
EUR 234

LZTR1 Blocking Peptide

DF10067-BP 1mg
EUR 234

ZNF441 Blocking Peptide

DF10068-BP 1mg
EUR 234

TUSC4 Blocking Peptide

DF10069-BP 1mg
EUR 234

TP73 Blocking Peptide

DF10070-BP 1mg
EUR 234

MINA Blocking Peptide

DF10071-BP 1mg
EUR 234

CI098 Blocking Peptide

DF10072-BP 1mg
EUR 234

DUX5 Blocking Peptide

DF10073-BP 1mg
EUR 234

CIC Blocking Peptide

DF10074-BP 1mg
EUR 234

NEB2 Blocking Peptide

DF10075-BP 1mg
EUR 234

MYCBP Blocking Peptide

DF10076-BP 1mg
EUR 234

ZNF577 Blocking Peptide

DF10078-BP 1mg
EUR 234

HIPK3 Blocking Peptide

DF10079-BP 1mg
EUR 234

POLM Blocking Peptide

DF10080-BP 1mg
EUR 234

NOLA1 Blocking Peptide

DF10081-BP 1mg
EUR 234

TF2L1 Blocking Peptide

DF10082-BP 1mg
EUR 234

VPS54 Blocking Peptide

DF10083-BP 1mg
EUR 234

RHCG Blocking Peptide

DF10084-BP 1mg
EUR 234

RTDR1 Blocking Peptide

DF10086-BP 1mg
EUR 234

JDP2 Blocking Peptide

DF10087-BP 1mg
EUR 234

CDYL1 Blocking Peptide

DF10088-BP 1mg
EUR 234

DUET Blocking Peptide

DF10089-BP 1mg
EUR 234

CDY1 Blocking Peptide

DF10090-BP 1mg
EUR 234

CCBE1 Blocking Peptide

DF10092-BP 1mg
EUR 234

COX7B Blocking Peptide

DF10093-BP 1mg
EUR 234

COX7A2L Blocking Peptide

DF10094-BP 1mg
EUR 234

COX82 Blocking Peptide

DF10095-BP 1mg
EUR 234

COX6A2 Blocking Peptide

DF10096-BP 1mg
EUR 234

COX6B2 Blocking Peptide

DF10097-BP 1mg
EUR 234

COX7A1 Blocking Peptide

DF10098-BP 1mg
EUR 234

CYBA Blocking Peptide

DF10099-BP 1mg
EUR 234

DEDD Blocking Peptide

DF10100-BP 1mg
EUR 234

DNAJB2 Blocking Peptide

DF10101-BP 1mg
EUR 234

EMID2 Blocking Peptide

DF10102-BP 1mg
EUR 234

FBF1 Blocking Peptide

DF10103-BP 1mg
EUR 234

GRIK5 Blocking Peptide

DF10104-BP 1mg
EUR 234

GRIP2 Blocking Peptide

DF10105-BP 1mg
EUR 234

IL20L2 Blocking Peptide

DF10106-BP 1mg
EUR 234

IL22RA2 Blocking Peptide

DF10107-BP 1mg
EUR 234

IL28RA Blocking Peptide

DF10108-BP 1mg
EUR 234

IFNW1 Blocking Peptide

DF10109-BP 1mg
EUR 234

IGFL2 Blocking Peptide

DF10110-BP 1mg
EUR 234

IGFL4 Blocking Peptide

DF10111-BP 1mg
EUR 234

IL1F7 Blocking Peptide

DF10112-BP 1mg
EUR 234

IL1F9 Blocking Peptide

DF10113-BP 1mg
EUR 234

IL31R Blocking Peptide

DF10114-BP 1mg
EUR 234

IFI6 Blocking Peptide

DF10115-BP 1mg
EUR 234

KRT84 Blocking Peptide

DF10116-BP 1mg
EUR 234

SETMAR Blocking Peptide

DF10118-BP 1mg
EUR 234

CCNB3 Blocking Peptide

DF10120-BP 1mg
EUR 234

MCM8 Blocking Peptide

DF10122-BP 1mg
EUR 234

STRN Blocking Peptide

DF10123-BP 1mg
EUR 234

KLF17 Blocking Peptide

DF10124-BP 1mg
EUR 234

ORC3 Blocking Peptide

DF10126-BP 1mg
EUR 234

PIK3C2G Blocking Peptide

DF10131-BP 1mg
EUR 234

NPR1 Blocking Peptide

DF10132-BP 1mg
EUR 234

NPR2 Blocking Peptide

DF10133-BP 1mg
EUR 234

CAMKK1 Blocking Peptide

DF10134-BP 1mg
EUR 234

CSNK1G3 Blocking Peptide

DF10135-BP 1mg
EUR 234

DYRK2 Blocking Peptide

DF10136-BP 1mg
EUR 234

NEK3 Blocking Peptide

DF10137-BP 1mg
EUR 234

PAK6 Blocking Peptide

DF10138-BP 1mg
EUR 234

PCTK2 Blocking Peptide

DF10139-BP 1mg
EUR 234

SNF1LK2 Blocking Peptide

DF10140-BP 1mg
EUR 234

RIPK3 Blocking Peptide

DF10141-BP 1mg
EUR 234

TSSK6 Blocking Peptide

DF10142-BP 1mg
EUR 234

MRGPRX2 indicators its significance in cutaneous mast cell biology: Does MRGPRX2 be part of mast cells and atopic dermatitis?

 

The invention of MRGPRX2 marks a necessary change in MC biology, explaining non-IgE-mediated scientific phenomena relying on MCs. As receptor for quite a few remedy, MRGPRX2 is important to drug-induced hypersensitivity.

Nonetheless, not solely remedy, however moreover endogenous mediators like neuropeptides and host safety peptides activate MRGPRX2, suggesting its broad affect in cutaneous pathophysiology.

Proper right here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which assist MCs and shall be altered in pores and pores and skin points, and briefly contact on the purposeful packages elicited by MRGPRX2 ligation. Analysis in Mrgprb2-deficient mice (the murine ortholog) help illuminate MRGPRX2’s function in effectively being and sickness.

Present advances on this model assist the long-suspected operational unit between MCs and nerves, with MRGPRX2 being an vital component. Based on the restricted proof for a big contribution of FcεRI/IgE-activated MCs to atopic dermatitis (AD), we develop the hypothesis that MRGPRX2 constitutes the missing hyperlink connecting MCs and AD, a minimum of in chosen endotypes.

Help comes from the multifold changes inside the MC-neuronal system of AD pores and pores and skin (e.g. bigger density of MCs and nearer connections between MCs and nerves, elevated PAR-2/Substance P).

We theorize that these deregulations suffice to impress AD, nonetheless exterior triggers, numerous which activating MRGPRX2 themselves (e.g. Staphylococcus aureus) extra feed into the loop. Itch, most likely probably the most burdensome hallmark of AD, is usually non-histaminergic nonetheless tryptase-dependent, and tryptase is preferentially launched upon MRGPRX2 activation. On account of MRGPRX2 is a very energetic evaluation space, a couple of of the current gaps are susceptible to be closed shortly.

Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Preliminary Part

 

By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that preserve distinctive contractile properties. Their dynamic nature is vital for neuronal biology along with the establishment of polarity, progress cone formation and motility, axon progress all through enchancment (and axon regeneration inside the grownup), radial and longitudinal axonal stress, and synapse formation and efficiency.

On this overview, we speak in regards to the current information on the spatial distribution and efficiency of the actomyosin cytoskeleton in quite a few axonal compartments.

We highlight a couple of of the plain contradictions and open questions inside the space, along with the place of NMII inside the regulation of axon progress and regeneration, the possibility that NMII structural affiliation alongside the axon shaft would possibly administration every radial and longitudinal contractility, and the mechanism and purposeful goal underlying NMII enrichment inside the axon preliminary part.

With the advances in reside cell imaging and super choice microscopy, it is anticipated that inside the near future the spatial distribution of NMII inside the axon, and the mechanisms by which it participates in axonal biology is perhaps extra untangled.

Casamino Acid

CB3060 100g
EUR 74.62

Chicoric acid

C158-10MG 10 mg
EUR 115.2

Chicoric acid

C158-25MG 25 mg
EUR 176.4

Cyclopiazonic acid

C192-1MG 1 mg
EUR 135.6

Cyclopiazonic acid

C192-5MG 5 mg
EUR 382.8

Lithocholic Acid

A8463-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Lithocholic acid (LCA) is a toxic secondary bile acid, causing intrahepatic cholestasis, which has tumor-promoting activity.

Lithocholic Acid

A8463-50 50 mg
EUR 157.2
Description: Lithocholic acid (LCA) is a toxic secondary bile acid, causing intrahepatic cholestasis, which has tumor-promoting activity.

Piromidic Acid

A8502-10 10 mg
EUR 129.6
Description: Shown to have antibacterial properties.

Piromidic Acid

A8502-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Shown to have antibacterial properties.

Piromidic Acid

A8502-50 50 mg
EUR 199.2
Description: Shown to have antibacterial properties.

Dihydroaeruginoic acid

D052-25MG 25 mg
EUR 804

Dihydroaeruginoic acid

D052-5MG 5 mg
EUR 255.6

Dipicolinic acid

D084-25MG 25 mg
EUR 285.6

Dipicolinic acid

D084-5MG 5 mg
EUR 106.8

Penicillic Acid

C3438-10 10 mg
EUR 170.4
Description: Penicillic acid is synthesized by a large number of fungi, such as P. puberulum, Penicillium stoloniferum, P. eye/opium Penicillium martensii, Penicillium thomii. The synthesis of this secondary metabolite has little or no taxonomic significance [1].

Penicillic Acid

C3438-25 25 mg
EUR 324
Description: Penicillic acid is synthesized by a large number of fungi, such as P. puberulum, Penicillium stoloniferum, P. eye/opium Penicillium martensii, Penicillium thomii. The synthesis of this secondary metabolite has little or no taxonomic significance [1].

Ascorbic Acid

CA052-010 100g
EUR 92.4

Ascorbic Acid

CA052-050 500g
EUR 157.2

Fusaric Acid

C5062-250 250 mg
EUR 174
Description: Fusaric acid is a mycotoxin produced by several species of Fusarium [1]. Mycotoxins are biologically active secondary fungal metabolites found as contaminants of food- and feedstuff. Mycotoxin is capable of causing disease and death in both humans and animals.

Fusaric Acid

C5062-500 500 mg
EUR 268.8
Description: Fusaric acid is a mycotoxin produced by several species of Fusarium [1]. Mycotoxins are biologically active secondary fungal metabolites found as contaminants of food- and feedstuff. Mycotoxin is capable of causing disease and death in both humans and animals.

Tienilic Acid

C5345-10 10 mg
EUR 223.2
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Tienilic Acid

C5345-25 25 mg
EUR 495.6
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Tienilic Acid

C5345-5 5 mg
EUR 157.2
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Tienilic Acid

C5345-50 50 mg
EUR 834
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Eicosatetraynoic Acid

C5515-10 10 mg
EUR 189.6
Description: Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1]. Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins.

Eicosatetraynoic Acid

C5515-25 25 mg
EUR 369.6
Description: Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1]. Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins.

Eicosatetraynoic Acid

C5515-50 50 mg
EUR 607.2
Description: Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1]. Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins.

?-Linolenic Acid

C5518-1000 1 g
EUR 313.2
Description: Gamma-linolenic acid is a weak Leukotriene B4 (LTB4) receptor antagonist.Gamma-linolenic acid (GLA), an omega-6 fatty acid, is an essential fatty acid necessary for human health. You have to get them through food.

?-Linolenic Acid

C5518-250 250 mg
EUR 164.4
Description: Gamma-linolenic acid is a weak Leukotriene B4 (LTB4) receptor antagonist.Gamma-linolenic acid (GLA), an omega-6 fatty acid, is an essential fatty acid necessary for human health. You have to get them through food.

Evernic Acid

C5610-100 100 mg
EUR 486
Description: Evernic Acid is an inhibitor of two key plasmodial FAS-II enzymes PfFabZ and PfFabIThe Type II fatty acid synthase (FAS) system catalysed fatty acid biosynthesis in most bacteria.

Evernic Acid

C5610-250 250 mg
EUR 912
Description: Evernic Acid is an inhibitor of two key plasmodial FAS-II enzymes PfFabZ and PfFabIThe Type II fatty acid synthase (FAS) system catalysed fatty acid biosynthesis in most bacteria.

Evernic Acid

C5610-50 50 mg
EUR 315.6
Description: Evernic Acid is an inhibitor of two key plasmodial FAS-II enzymes PfFabZ and PfFabIThe Type II fatty acid synthase (FAS) system catalysed fatty acid biosynthesis in most bacteria.

?-Guanidinoglutaric Acid

C5708-100 100 mg
EUR 549.6
Description: ?-Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2.69 ?M [1].

?-Guanidinoglutaric Acid

C5708-50 50 mg
EUR 339.6
Description: ?-Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2.69 ?M [1].

Folic Acid

AG062 1 mg
EUR 627.6

Ferulic Acid

AG130 1 mg
EUR 627.6

Benzoic Acid

AG153 1 mg
EUR 627.6

Trichlorophenoxyacetic Acid

AG169 1 mg
EUR 627.6

Tenuazonic acid

AG183 1 mg
EUR 627.6

Glycochenodeoxycholic acid

AG216 1 mg
EUR 627.6

Arsanilic acid

AG255 1 mg
EUR 627.6

Gibberellic acid

AG268 1 mg
EUR 627.6

Asterric Acid

C4549-1 1 mg
EUR 351.6
Description: IC50: 10 ?M for ET-1 binding to the ETA receptor ofA10 cellsAsterric Acid is an ETA receptor inhibitor. Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells.

Asterric Acid

C4549-5 5 mg
EUR 1155.6
Description: IC50: 10 ?M for ET-1 binding to the ETA receptor ofA10 cellsAsterric Acid is an ETA receptor inhibitor. Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells.

Maslinic Acid

C4832-10 10 mg
EUR 339.6
Description: Maslinic acid is a pentacyclic triterpene existed in the protective wax-like coating of the leaves and fruit of Olea europaea L [1]. Maslinic acid is an inhibitor of NO, H2O2, IL-6 and TNF-?.

Maslinic Acid

C4832-25 25 mg
EUR 673.2
Description: Maslinic acid is a pentacyclic triterpene existed in the protective wax-like coating of the leaves and fruit of Olea europaea L [1]. Maslinic acid is an inhibitor of NO, H2O2, IL-6 and TNF-?.

Maslinic Acid

C4832-5 5 mg
EUR 217.2
Description: Maslinic acid is a pentacyclic triterpene existed in the protective wax-like coating of the leaves and fruit of Olea europaea L [1]. Maslinic acid is an inhibitor of NO, H2O2, IL-6 and TNF-?.

Ethacrynic Acid

C4125-1000 1 g
EUR 145.2

Ethacrynic Acid

C4125-10000 10 g
EUR 818.4

Ethacrynic Acid

C4125-5000 5 g
EUR 459.6

Fusidic acid

F019-100MG 100 mg
EUR 100.8

Fusidic acid

F019-1G 1 g
EUR 349.2

Fuchsin acid

FB0469 100g
EUR 118.46

Pressinoic Acid

5-01806 4 x 5mg Ask for price

Asterric Acid

A132-1MG 1 mg
EUR 313.2

Asterric Acid

A132-5MG 5 mg
EUR 1006.8

Zoledronic Acid

A1352-100 100 mg
EUR 268.8
Description: Zoledronic acid, one of the most potent nitrogen-containing bisphosphonates, induces anti-proliferative and apoptotic effects on multiple myeloma cell lines in vitro by activating protein kinase C. Zoledronic acid also inhibits proliferation of human foet

Zoledronic Acid

A1352-25 25 mg
EUR 129.6
Description: Zoledronic acid, one of the most potent nitrogen-containing bisphosphonates, induces anti-proliferative and apoptotic effects on multiple myeloma cell lines in vitro by activating protein kinase C. Zoledronic acid also inhibits proliferation of human foet

Zoledronic Acid

A1352-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Zoledronic acid, one of the most potent nitrogen-containing bisphosphonates, induces anti-proliferative and apoptotic effects on multiple myeloma cell lines in vitro by activating protein kinase C. Zoledronic acid also inhibits proliferation of human foet

Anacardic Acid

A160-10MG 10mg
EUR 144

Anacardic Acid

A160-250MG 250mg
EUR 298.8

Lithocholic acid

2187-1G
EUR 138

Lithocholic acid

2187-5G
EUR 326.4

MB acid

40076 5MG
EUR 384
Description: Minimum order quantity: 1 unit of 5MG

Kainic acid

2279-25
EUR 457.2

Kainic acid

2279-5
EUR 170.4

Caffeic acid

2303-250
EUR 235.2

Caffeic acid

2303-50
EUR 117.6

Carnosic Acid

2075-25
EUR 523.2

Carnosic Acid

2075-5
EUR 176.4

Oleanolic Acid

1731-100
EUR 138

Oleanolic Acid

1731-500
EUR 398.4

Rosmarinic Acid

1843-250
EUR 274.8

Rosmarinic Acid

1843-50
EUR 138

Anacardic Acid

1849-25
EUR 444

Anacardic Acid

1849-5
EUR 176.4

Mycophenolic Acid

1882-250
EUR 352.8

Mycophenolic Acid

1882-50
EUR 138

ICG acid

189 5 mg
EUR 262.8

Heptelidic Acid

2215-1000
EUR 588

Heptelidic Acid

2215-250
EUR 261.6

Retinoic acid

2218-250
EUR 405.6

Retinoic acid

2218-50
EUR 151.2

(+)-Abscisic acid

2543-1
EUR 144

(+)-Abscisic acid

2543-5
EUR 379.2

Itaconic acid

2576-1G
EUR 144

Itaconic acid

2576-5G
EUR 288

Gambogic acid

2785-25
EUR 652.8

Gambogic acid

2785-5
EUR 210

Chenodeoxycholic acid

2831-1G
EUR 144

Chenodeoxycholic acid

2831-25G
EUR 574.8

Chenodeoxycholic acid

2831-5G
EUR 222

Arachidonic Acid

1505-100
EUR 202.8

Aurintricarboxylic acid

1506-1000
EUR 164.4

Okadaic acid

1543-025
EUR 188.4

Okadaic acid

1543-100
EUR 379.2

Betulinic acid

1552-100
EUR 450

Betulinic acid

1552-25
EUR 170.4

Mycophenolic acid

10-030 500 mg
EUR 539.16
Description: Antibiotic [1]. Shows antiviral, antifungal and antitumor properties [1, 2]. Immunosuppressive drug used to prevent rejection in organ transplantation, rheumatoid arthritis, and psoriasis [3-6, 13]. Potent reversible inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), leading to depletion of GMP and interruption of the de novo synthesis of purine nucleotides necessary for B and T lymphocyte proliferation [7, 8]. Inhibits the type II IMPDH isoform (IMPDH-2) 5-fold more potently compared to type I isoform [11]. Inhibits RNA and DNA synthesis [13]. Inducible nitric oxide synthase (iNOS/NOS II) inhibitor [8, 10]. Apoptosis and necrosis inducer [9, 12]. Novel type of inhibitor against RNA guanylyltransferases [14]. Inhibits TNF-α-stimulated MAPK/NF-κB and ROS generation [15]. Autophagy suppressor. Broad-spectrum antiviral compound with inhibitory activity against different coronavirus, including SARS-CoV, MERS-CoV and SARS-CoV-2, cause of COVID-19. It binds to the active site of SARS-CoV-2 papain-like protease (PLpro) possibly inhibiting viral replication.

Betulinic acid

A3237-100 100 mg
EUR 129.6
Description: Betulinic acid is a natural pentacyclic triterpenoid that displays anti-HIV and antitumor activity. Betulinic acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Betulinic acid

A3237-200 200 mg
EUR 177.6
Description: Betulinic acid is a natural pentacyclic triterpenoid that displays anti-HIV and antitumor activity. Betulinic acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Betulinic acid

A3237-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Betulinic acid is a natural pentacyclic triterpenoid that displays anti-HIV and antitumor activity. Betulinic acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Betulinic acid

A3237-500 500 mg
EUR 309.6
Description: Betulinic acid is a natural pentacyclic triterpenoid that displays anti-HIV and antitumor activity. Betulinic acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism.

Gambogic Acid

A3424-10 10 mg
EUR 192
Description: Gambogic acid (GA) is an inducer of apoptosis with EC50 value of 0.78-1.64 ?M for caspases and with IC50 values of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 ?M for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1, respectively.

Gambogic Acid

A3424-25 25 mg
EUR 261.6
Description: Gambogic acid (GA) is an inducer of apoptosis with EC50 value of 0.78-1.64 ?M for caspases and with IC50 values of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 ?M for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1, respectively.

Gambogic Acid

A3424-5 5 mg
EUR 150
Description: Gambogic acid (GA) is an inducer of apoptosis with EC50 value of 0.78-1.64 ?M for caspases and with IC50 values of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 ?M for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1, respectively.

Gambogic Acid

A3424-5.1 10 mM (in 1mL DMSO)
EUR 184.8
Description: Gambogic acid (GA) is an inducer of apoptosis with EC50 value of 0.78-1.64 ?M for caspases and with IC50 values of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 ?M for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1, respectively.

Kainic acid

20-abx076647
  • EUR 444.00
  • EUR 1262.40
  • 10 mg
  • 50 mg

Quisqualic Acid

20-abx076651
  • EUR 510.00
  • EUR 1412.40
  • 10 mg
  • 50 mg

Retinoic acid

20-abx076656
  • EUR 292.80
  • EUR 243.60
  • 250 mg
  • 50 mg

Okadaic acid

20-abx076703
  • EUR 627.60
  • EUR 309.60
  • 100 ug
  • 20 ug

(+)-Abscisic Acid

abx076833-1mg 1 mg
EUR 493.2

Tropodithietic acid

abx076844-1mg 1 mg
EUR 477.6

Abscisic Acid

abx082046-100mg 100 mg
EUR 243.6

Folic acid

abx082263-100g 100 g
EUR 376.8

Folic acid

20-abx082265
  • EUR 376.80
  • EUR 276.00
  • 100 g
  • 25 g

Nicotinic acid

20-abx082297
  • EUR 292.80
  • EUR 243.60
  • 100 g
  • 25 g

Maleic acid

abx082326-100g 100 g
EUR 226.8

Pyruvic acid

20-abx082337
  • EUR 343.20
  • EUR 243.60
  • 100 g
  • 25 g

Boric acid

abx082355-500g 500 g
EUR 243.6

Gibberellic acid

20-abx082365
  • EUR 276.00
  • EUR 226.80
  • 1 g
  • 250 mg

Boric acid

abx082375-500g 500 g
EUR 226.8

Pyruvic acid

20-abx082493
  • EUR 276.00
  • EUR 226.80
  • 100 g
  • 25 g

Lipoteichoic Acid

abx087002-1mg 1 mg
EUR 343.2

Calconcarboxylic Acid

abx090682-25g 25 g
EUR 243.6

Carnosic acid

20-abx076520
  • EUR 292.80
  • EUR 477.60
  • 10 mg
  • 50 mg

Betulinic Acid

20-abx076536
  • EUR 292.80
  • EUR 560.40
  • 10 mg
  • 50 mg

Anacardic acid

A4488-10 10 mg
EUR 142.8
Description: IC50: Noncompetitively inhibit histone acetyltransferase (HAT) activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT inhibitor of p300.

Anacardic acid

A4488-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: IC50: Noncompetitively inhibit histone acetyltransferase (HAT) activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT inhibitor of p300.

Anacardic acid

A4488-50 50 mg
EUR 393.6
Description: IC50: Noncompetitively inhibit histone acetyltransferase (HAT) activity in prostate cancer with an IC50 value of about 5.0 M.Anacardic acid (AA) is commonly regarded as a non-specific HAT inhibitor of p300.

Okadaic acid

A4540-.05 50 µg
EUR 182.4
Description: Okadaic acid is a potent inhibitor of protein phosphatase 1/2A with IC50 values of 19 nM and 0.2 nM for protein phosphatase 1 and protein phosphatase 2A, respectively [1].

Okadaic acid

A4540-.1 100 µg
EUR 292.8
Description: Okadaic acid is a potent inhibitor of protein phosphatase 1/2A with IC50 values of 19 nM and 0.2 nM for protein phosphatase 1 and protein phosphatase 2A, respectively [1].

Ellagic acid

A2306-25 25 mg
EUR 199.2
Description: Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk?and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutat

Ellagic acid

A2306-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk?and FGR respectively). Exhibits antioxidant, antitumor and anticarcinogenic activity and also inhibits glutat

Ascorbic acid

A8158-10 10 mg
EUR 170.4
Description: Ascorbic acid is the recommended reagent for the reduction of Copper(II)-TBTA complex into active Copper(I) form.

Nordihydroguaiaretic acid

A3664-100 100 mg
EUR 126
Description: Description: IC50 Value: N/A Nordihydroguaiaretic acid (NDGA) is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo.

Nordihydroguaiaretic acid

A3664-500 500 mg
EUR 195.6
Description: Description: IC50 Value: N/A Nordihydroguaiaretic acid (NDGA) is a natural phenolic compound isolated from the creosote bush Larrea divaricata, which has anti-tumor activities both in vitro and in vivo.

Oseltamivir acid

A3689-10 10 mg
EUR 172.8
Description: Oseltamivir is an inhibitor of influenza neuraminidase [1].Oseltamivir is a prodrug that is converted by intestinal and/or hepatic esterases to the neuraminidase inhibitor molecule, oseltamivir carboxylate.

Oseltamivir acid

A3689-5.1 10 mM (in 1mL DMSO)
EUR 129.6
Description: Oseltamivir is an inhibitor of influenza neuraminidase [1].Oseltamivir is a prodrug that is converted by intestinal and/or hepatic esterases to the neuraminidase inhibitor molecule, oseltamivir carboxylate.

Oseltamivir acid

A3689-50 50 mg
EUR 315.6
Description: Oseltamivir is an inhibitor of influenza neuraminidase [1].Oseltamivir is a prodrug that is converted by intestinal and/or hepatic esterases to the neuraminidase inhibitor molecule, oseltamivir carboxylate.

Glycerophosphoric acid

20-abx180002
  • EUR 260.40
  • EUR 944.40
  • EUR 427.20
  • 1 g
  • 25 g
  • 5 g

Cyclobutylboronic Acid

20-abx180715
  • EUR 410.40
  • EUR 828.00
  • 1 g
  • 5 g

Hendecanoic acid

20-abx180775
  • EUR 376.80
  • EUR 276.00
  • 100 g
  • 25 g

Heptadecanoic acid

20-abx180776
  • EUR 260.40
  • EUR 460.80
  • EUR 326.40
  • 1 g
  • 25 g
  • 5 g

Methanesulfonylacetic Acid

20-abx180797
  • EUR 292.80
  • EUR 1011.60
  • EUR 477.60
  • 1 g
  • 25 g
  • 5 g

Octadecanedioic acid

20-abx180854
  • EUR 861.60
  • EUR 326.40
  • EUR 1528.80
  • EUR 577.20
  • 10 g
  • 1 g
  • 25 g
  • 5 g

pentadecanoic acid

20-abx180857
  • EUR 393.60
  • EUR 260.40
  • 25 g
  • 5 g

Pyromeconic acid

20-abx180870
  • EUR 627.60
  • EUR 1412.40
  • 1 g
  • 5 g

Tridecanoic acid

20-abx180912
  • EUR 260.40
  • EUR 393.60
  • 1 g
  • 5 g

Cyclopentylboronic Acid

20-abx181255
  • EUR 861.60
  • EUR 393.60
  • EUR 2781.60
  • EUR 260.40
  • 100 g
  • 25 g
  • 500 g
  • 5 g

Cyclopropylacetic acid

20-abx181256
  • EUR 2682.00
  • EUR 978.00
  • 100 g
  • 25 g

Hydroxymalonic acid

20-abx181299
  • EUR 944.40
  • EUR 2414.40
  • 1 g
  • 5 g

Tridecanedioic acid

20-abx181373
  • EUR 393.60
  • EUR 276.00
  • EUR 828.00
  • 100 g
  • 25 g
  • 500 g

Coumalic acid

20-abx182402
  • EUR 760.80
  • EUR 292.80
  • 100 g
  • 10 g

Cyclohexylboronic Acid

20-abx182406
  • EUR 243.60
  • EUR 610.80
  • EUR 343.20
  • 1 g
  • 25 g
  • 5 g

Ethylboronic Acid

20-abx182474
  • EUR 744.00
  • EUR 292.80
  • EUR 210.00
  • EUR 376.80
  • EUR 243.60
  • 100 g
  • 10 g
  • 1 g
  • 25 g
  • 5 g

Isopropylboronic Acid

20-abx182498
  • EUR 944.40
  • EUR 309.60
  • EUR 410.40
  • EUR 260.40
  • 100 g
  • 10 g
  • 25 g
  • 5 g

Methylboronic Acid

20-abx182574
  • EUR 393.60
  • EUR 260.40
  • EUR 910.80
  • EUR 210.00
  • 100 g
  • 25 g
  • 500 g
  • 5 g

oxalic acid

20-abx182613
  • EUR 17181.60
  • EUR 3834.00
  • EUR 11101.20
  • 10 g
  • 1 g
  • 5 g

Chenodeoxycholic acid

abx183934-100g 100 g
EUR 276

Cholic acid

abx183940-100g 100 g
EUR 360

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