August 15, 2022
ucidevcell

Dewetting: From Physics to the Biology of Intoxicated Cells

Dewetting: From Physics to the Biology of Intoxicated Cells

 Pathogenic micro organism colonize or disseminate into cells and tissues by inducing large-scale remodeling of host membranes. The bodily phenomena underpinning these big membrane extension and deformation are poorly understood. Invasive strategies of pathogens have been simply recently enriched by the define of a spectacular mode of opening of huge transendothelial cell macroaperture (TEM) tunnels correlated to the dissemination of EDIN-producing strains of Staphylococcus aureus by means of a hematogenous route or to the induction of gelatinous edema triggered by the edema toxin from Bacillus anthracis.

Remarkably, these extraordinarily dynamic tunnels shut shortly after they attain a maximal measurement. Opening and closure of TEMs in cells lasts for hours with out inducing endothelial cell demise. Multidisciplinary analysis have started to produce a broader perspective of every the molecular determinants controlling cytoskeleton group at newly curved membranes generated by the opening of TEMs and the bodily processes controlling the dynamics of these tunnels.

Proper right here we speak in regards to the analogy between the opening of TEM tunnels and the bodily concepts of dewetting, stemming from a parallel between membrane stress and ground stress. This analogy provides a broad framework to analysis biophysical constraints in cell membrane dynamics and their diversion by positive invasive microbial brokers

Present advances in myeloid-derived suppressor cell biology

 

In latest occasions, discovering out the place of myeloid-derived suppressor cells (MDSCs) in numerous pathological inflammatory conditions has become a very energetic evaluation area. Although the place of MDSCs in most cancers is relatively successfully established, their place in non-cancerous pathological conditions stays in its infancy resulting in rather a lot confusion. Our targets on this overview are to cope with some present advances in MDSC evaluation in order to lower such confusion and to produce an notion into their function inside the context of various illnesses.

The following issues is perhaps significantly centered upon:

(1) definition and characterization of MDSCs;

(2) whether or not or not all MDSC populations embrace immature cells;

(3) technical factors in MDSC isolation, estimation and characterization;

(4) the origin of MDSCs and their anatomical distribution in effectively being and sickness;

(5) mediators of MDSC development and accumulation;

(6) parts that determine the expansion of 1 MDSC inhabitants over the other;

(7) the Yin and Yang roles of MDSCs. Moreover, the capabilities of MDSCs is perhaps addressed all by the textual content material.

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CBFB Blocking Peptide

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MAPKAPK3 Blocking Peptide

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MOB3C Blocking Peptide

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DPF2 Blocking Peptide

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TAF15 Blocking Peptide

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FAM84B Blocking Peptide

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COL19A1 Blocking Peptide

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CYP2W1 Blocking Peptide

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RAD21 Blocking Peptide

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MRPS9 Blocking Peptide

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MRPL41 Blocking Peptide

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MRPL48 Blocking Peptide

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GHITM Blocking Peptide

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NXPH3 Blocking Peptide

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PP15 Blocking Peptide

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LONP2 Blocking Peptide

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PEX10 Blocking Peptide

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PRPF39 Blocking Peptide

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PPM1K Blocking Peptide

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RSAD1 Blocking Peptide

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Renin Blocking Peptide

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SH2D2A Blocking Peptide

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SHIP2 Blocking Peptide

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CD225 Blocking Peptide

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CD276 Blocking Peptide

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CD300d Blocking Peptide

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GPR10 Blocking Peptide

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GPCR135 Blocking Peptide

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STAT5 Blocking Peptide

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TGFBR2 Blocking Peptide

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ABL1 Blocking Peptide

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SPHK2 Blocking Peptide

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RPS6KC1 Blocking Peptide

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MMTAG2 Blocking Peptide

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MRG15 Blocking Peptide

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CADM1 Blocking Peptide

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APPBP2 Blocking Peptide

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CEP135 Blocking Peptide

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EIF3J Blocking Peptide

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MRPS22 Blocking Peptide

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RIMS4 Blocking Peptide

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RHOBTB3 Blocking Peptide

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GPR40 Blocking Peptide

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COX10 Blocking Peptide

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ALT2 Blocking Peptide

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DZIP3 Blocking Peptide

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CaMK4 Blocking Peptide

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Dematin Blocking Peptide

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TBX10 Blocking Peptide

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PSKH1 Blocking Peptide

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EPHA1 Blocking Peptide

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MKK4 Blocking Peptide

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ID4 Blocking Peptide

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FOXK1 Blocking Peptide

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TRIM25 Blocking Peptide

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DOK7 Blocking Peptide

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BTBD6 Blocking Peptide

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BEGAIN Blocking Peptide

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YTHDF1 Blocking Peptide

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PBOV1 Blocking Peptide

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BCA3 Blocking Peptide

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SERINC1 Blocking Peptide

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ZC3H7B Blocking Peptide

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ARMCX3 Blocking Peptide

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STAG3 Blocking Peptide

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TCFL5 Blocking Peptide

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SUR2 Blocking Peptide

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CHKB Blocking Peptide

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ERGIC3 Blocking Peptide

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DYRK1B Blocking Peptide

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SUPT16H Blocking Peptide

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IRAK3 Blocking Peptide

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CDC6 Blocking Peptide

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ARRDC2 Blocking Peptide

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CADM2 Blocking Peptide

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CARD11 Blocking Peptide

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DNAJB4 Blocking Peptide

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GSPT1 Blocking Peptide

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MRGPRX2 indicators its significance in cutaneous mast cell biology: Does MRGPRX2 be part of mast cells and atopic dermatitis?

 

The invention of MRGPRX2 marks a necessary change in MC biology, explaining non-IgE-mediated scientific phenomena relying on MCs. As receptor for quite a few remedy, MRGPRX2 is important to drug-induced hypersensitivity.

Nonetheless, not solely remedy, however moreover endogenous mediators like neuropeptides and host safety peptides activate MRGPRX2, suggesting its broad affect in cutaneous pathophysiology.

Proper right here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which assist MCs and shall be altered in pores and pores and skin points, and briefly contact on the purposeful packages elicited by MRGPRX2 ligation. Analysis in Mrgprb2-deficient mice (the murine ortholog) help illuminate MRGPRX2’s function in effectively being and sickness.

Present advances on this model assist the long-suspected operational unit between MCs and nerves, with MRGPRX2 being an vital component. Based on the restricted proof for a big contribution of FcεRI/IgE-activated MCs to atopic dermatitis (AD), we develop the hypothesis that MRGPRX2 constitutes the missing hyperlink connecting MCs and AD, a minimum of in chosen endotypes.

Help comes from the multifold changes inside the MC-neuronal system of AD pores and pores and skin (e.g. bigger density of MCs and nearer connections between MCs and nerves, elevated PAR-2/Substance P).

We theorize that these deregulations suffice to impress AD, nonetheless exterior triggers, numerous which activating MRGPRX2 themselves (e.g. Staphylococcus aureus) extra feed into the loop. Itch, most likely probably the most burdensome hallmark of AD, is usually non-histaminergic nonetheless tryptase-dependent, and tryptase is preferentially launched upon MRGPRX2 activation. On account of MRGPRX2 is a very energetic evaluation space, a couple of of the current gaps are susceptible to be closed shortly.

Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Preliminary Part

 

By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that preserve distinctive contractile properties. Their dynamic nature is vital for neuronal biology along with the establishment of polarity, progress cone formation and motility, axon progress all through enchancment (and axon regeneration inside the grownup), radial and longitudinal axonal stress, and synapse formation and efficiency.

On this overview, we speak in regards to the current information on the spatial distribution and efficiency of the actomyosin cytoskeleton in quite a few axonal compartments.

We highlight a couple of of the plain contradictions and open questions inside the space, along with the place of NMII inside the regulation of axon progress and regeneration, the possibility that NMII structural affiliation alongside the axon shaft would possibly administration every radial and longitudinal contractility, and the mechanism and purposeful goal underlying NMII enrichment inside the axon preliminary part.

With the advances in reside cell imaging and super choice microscopy, it is anticipated that inside the near future the spatial distribution of NMII inside the axon, and the mechanisms by which it participates in axonal biology is perhaps extra untangled.

Salicylic acid

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Sorbic acid

SB0899 500g
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Succinic acid

SD0496 500g
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Anacardic Acid

M37000 5 mg
EUR 183.4
Description: kits suitable for this type of research

Valproic Acid

M41002 500 mg
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Ginkgolic acid

M75004 5 mg
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Mucic acid

MD1225 50g
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Nalidixic Acid

N011-100G 100 g
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Nalidixic Acid

N011-25G 25 g
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Neochlorogenic acid

N050-10MG 10 mg
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Neochlorogenic acid

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Oxolinic acid

O002-25G 25 g
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Oxolinic acid

O002-5G 5 g
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Lactobionic acid

L017-25G 25 g
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Mycophenolic Acid

M012-250MG 250 mg
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Mycophenolic Acid

M012-50MG 50 mg
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Pipemidic acid

P009-100G 100 g
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Pipemidic acid

P009-10G 10 g
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Pseudomonic acid

P095-100MG 100 mg
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Pseudomonic acid

P095-25MG 25 mg
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Zoledronic Acid

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Retinoic acid

HY-14649 10mM/1mL
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Levomefolic acid

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Minodronic acid

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Folic acid

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Pirinixic acid

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Folinic acid

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Lipoic acid

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Ethylmalonic acid

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Octanoic acid

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(-)-Aspartic acid

HY-42068 5g
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Asparagusic acid

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Chenodeoxycholic Acid

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Glyoxalic acid

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Benzenebutyric acid

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Pamidronic acid

HY-B0012 10mM/1mL
EUR 172

Risedronic acid

HY-B0148 500mg
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Tranexamic acid

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Salicylic acid

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EUR 160

Lithocholic acid

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EUR 108

Ellagic acid

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EUR 108

Etidronic acid

HY-B0302 1g
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Tolfenamic Acid

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EUR 108

Nalidixic acid

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EUR 108

Mycophenolic acid

HY-B0421 1g
EUR 185

Niflumic acid

HY-B0493 10mM/1mL
EUR 141

Ibandronic acid

HY-B0515A 100mg
EUR 215

Cyclamic acid

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EUR 533

Mefenamic acid

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Hyaluronic acid

HY-B0633A 50mg
EUR 119

Eicosapentaenoic Acid

HY-B0660 10mM/1mL
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Azelaic acid

HY-B0704 10mM/1mL
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Carglumic Acid

HY-B0711 200mg
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Fenofibric acid

HY-B0760 500mg
EUR 108

Betulinic acid

HY-10529 10mM/1mL
EUR 131

Valproic acid

HY-10585 10mM/1mL
EUR 113

Gadopentetic acid

HY-107353 100mg
EUR 108

Arundic Acid

HY-107661 5mg
EUR 337

Medronic acid

HY-108309 10mM/1mL
EUR 113

Arachidonic acid

HY-109590 10mg
EUR 131

Aminomalonic acid

HY-112052 100mg
EUR 223

Urocanic acid

HY-113008 500mg
EUR 108

Hydroxypyruvic acid

HY-113013 5mg
EUR 371

Elaidic acid

HY-113016 100mg
EUR 108

Mevalonic acid

HY-113071 5mg
EUR 268

Argininic acid

HY-113079 5mg
EUR 223

Paullinic acid

HY-113094 10mg
EUR 302

Indolelactic acid

HY-113099 10mg
EUR 131

Eicosadienoic acid

HY-113130 25mg
EUR 119

Bovinic acid

HY-113162 10mg
EUR 153

Ursocholic acid

HY-113212 10mg
EUR 452

Hydroxyphenyllactic acid

HY-113219 50mg
EUR 176

Oxoadipic acid

HY-113227 10mg
EUR 268

Dihydrofolic acid

HY-113267 5mg
EUR 337

Homogentisic acid

HY-113283 10mg
EUR 142

Ureidopropionic acid

HY-113285 100mg
EUR 153

Citraconic acid

HY-113298 5g
EUR 119

Hexacosanoic acid

HY-113301 10mg
EUR 119

Aminoadipic acid

HY-113328 1g
EUR 153

Nicotinuric acid

HY-113353 10mM/1mL
EUR 126

Petroselinic acid

HY-113362 10mM/1mL
EUR 113

Guanidinosuccinic acid

HY-113373 100mg
EUR 257

Imidazoleacetic acid

HY-113413 50mg
EUR 223

Obeticholic acid

HY-12222 100mg
EUR 383

Bempedoic acid

HY-12357 100mg
EUR 567

Eicosatetraynoic acid

HY-124108 1mg
EUR 160

Pentacosanoic acid

HY-124422 50mg
EUR 108

Glycodeoxycholic Acid

HY-125731 50mg
EUR 211

Phosphonoacetic acid

HY-128744 100mg
EUR 108

Oseltamivir (acid)

HY-13318 10mM/1mL
EUR 148

Fusidic acid

F019-100MG 100 mg
EUR 84

Fusidic acid

F019-1G 1 g
EUR 291

Hydrochloric acid

HC6025 2.5L
EUR 97.85

Benzophenonetetracarboxylic acid

HY-100511 100mg
EUR 257

Benzenepentacarboxylic Acid

HY-100512 500mg
EUR 160

Kynurenic acid

HY-100806 10mM/1mL
EUR 113

Quinolinic acid

HY-100807 1g
EUR 119

Spaglumic Acid

HY-100921 50mg
EUR 187

Docosatrienoic Acid

HY-101408 10mg
EUR 173

Vanilpyruvic acid

HY-101416 10mg
EUR 147

Bucloxic acid

HY-101581 20mg
EUR 1703

Methylmalonic acid

HY-103395 500mg
EUR 108

Fuchsin acid

FB0469 100g
EUR 98.72

Gallic acid

GB0476 250g
EUR 71.75

Chlorogenic acid

HY-N0055 10mM/1mL
EUR 126

Ferulic acid

HY-N0060 500mg
EUR 165

Ginkgolic Acid

HY-N0077 10mg
EUR 402

Gambogic Acid

HY-N0087 5mg
EUR 133

Shikimic acid

HY-N0130 100mg
EUR 119

Ursolic acid

HY-N0140 10mM/1mL
EUR 156

Oleanolic Acid

HY-N0156 500mg
EUR 278

Orotic acid

HY-N0157 10mM/1mL
EUR 126

Hyodeoxycholic acid

HY-N0169 100mg
EUR 119

Caffeic acid

HY-N0172 5g
EUR 147

Glycyrrhizic acid

HY-N0184 100mg
EUR 147

Asiatic acid

HY-N0194 100mg
EUR 337

Nordihydroguaiaretic acid

HY-N0198 100mg
EUR 119

Benzoic acid

HY-N0216 100mg
EUR 108

Echinocystic acid

HY-N0271 10mM/1mL
EUR 172

Corosolic acid

HY-N0280 10mg
EUR 250

Protocatechuic acid

HY-N0294 1g
EUR 133

Caftaric acid

HY-N0321 10mM/1mL
EUR 414

Cholic acid

HY-N0324 10mM/1mL
EUR 126

Syringic acid

HY-N0339 100mg
EUR 108

Pachymic acid

HY-N0371 50mg
EUR 1262

Homovanillic acid

HY-N0384 100mg
EUR 119

Succinic acid

HY-N0420 10mM/1mL
EUR 151

Cichoric Acid

HY-N0457 10mg
EUR 133

Roburic acid

HY-N0481 1mg
EUR 113

Gallic acid

HY-N0523 500mg
EUR 147

Rosmarinic acid

HY-N0529 100mg
EUR 173

Deoxycholic acid

HY-N0593 10mM/1mL
EUR 126

Deacetylasperulosidic Acid

HY-N0594 10mg
EUR 436

Cinnamic acid

HY-N0610A 10mM/1mL
EUR 113

Maslinic acid

HY-N0629 25mg
EUR 436

Carnosic acid

HY-N0644 50mg
EUR 223

(+)-Usnic acid

HY-N0656A 100mg
EUR 108

Vanillic acid

HY-N0708 10mM/1mL
EUR 113

Neochlorogenic acid

HY-N0722 10mg
EUR 326

Linoleic acid

HY-N0729 10mM/1mL
EUR 113

Isoferulic acid

HY-N0761 10mM/1mL
EUR 113

Cryptochlorogenic acid

HY-N0787 10mM/1mL
EUR 126

Phytic acid

HY-N0814 250mg
EUR 108

Lithospermic acid

HY-N0823 5mg
EUR 142

Palmitic acid

HY-N0830 10mM/1mL
EUR 113

Quillaic acid

HY-N0839 5mg
EUR 533

Glycocholic acid

HY-N1423 10mM/1mL
EUR 113

Glycoursodeoxycholic acid

HY-N1424 10mg
EUR 119

Citric acid

HY-N1428 100mg
EUR 108

Oleic acid

HY-N1446 10mM/1mL
EUR 299

Betulonic acid

HY-N1451 10mM/1mL
EUR 126

Kaurenoic acid

HY-N1469 5mg
EUR 186

Polygalic acid

HY-N1479 20mg
EUR 257

Ursonic acid

HY-N1486 10mg
EUR 380

Oleanonic acid

HY-N1487 50mg
EUR 119

Gibberellic acid

HY-N1964 100mg
EUR 108

Artemisic acid

HY-N1984 10mM/1mL
EUR 113

Chebulagic acid

HY-N1996 25mg
EUR 1047

Veratric acid

HY-N2007 10mM/1mL
EUR 113

Anacardic Acid

HY-N2020 25mg
EUR 234

Taurochenodeoxycholic acid

HY-N2027 50mg
EUR 119

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