September 19, 2020
ucidevcell

Dewetting: From Physics to the Biology of Intoxicated Cells

Dewetting: From Physics to the Biology of Intoxicated Cells

 Pathogenic micro organism colonize or disseminate into cells and tissues by inducing large-scale remodeling of host membranes. The bodily phenomena underpinning these big membrane extension and deformation are poorly understood. Invasive strategies of pathogens have been simply recently enriched by the define of a spectacular mode of opening of huge transendothelial cell macroaperture (TEM) tunnels correlated to the dissemination of EDIN-producing strains of Staphylococcus aureus by means of a hematogenous route or to the induction of gelatinous edema triggered by the edema toxin from Bacillus anthracis.

Remarkably, these extraordinarily dynamic tunnels shut shortly after they attain a maximal measurement. Opening and closure of TEMs in cells lasts for hours with out inducing endothelial cell demise. Multidisciplinary analysis have started to produce a broader perspective of every the molecular determinants controlling cytoskeleton group at newly curved membranes generated by the opening of TEMs and the bodily processes controlling the dynamics of these tunnels.

Proper right here we speak in regards to the analogy between the opening of TEM tunnels and the bodily concepts of dewetting, stemming from a parallel between membrane stress and ground stress. This analogy provides a broad framework to analysis biophysical constraints in cell membrane dynamics and their diversion by positive invasive microbial brokers

Present advances in myeloid-derived suppressor cell biology

 

In latest occasions, discovering out the place of myeloid-derived suppressor cells (MDSCs) in numerous pathological inflammatory conditions has become a very energetic evaluation area. Although the place of MDSCs in most cancers is relatively successfully established, their place in non-cancerous pathological conditions stays in its infancy resulting in rather a lot confusion. Our targets on this overview are to cope with some present advances in MDSC evaluation in order to lower such confusion and to produce an notion into their function inside the context of various illnesses.

The following issues is perhaps significantly centered upon:

(1) definition and characterization of MDSCs;

(2) whether or not or not all MDSC populations embrace immature cells;

(3) technical factors in MDSC isolation, estimation and characterization;

(4) the origin of MDSCs and their anatomical distribution in effectively being and sickness;

(5) mediators of MDSC development and accumulation;

(6) parts that determine the expansion of 1 MDSC inhabitants over the other;

(7) the Yin and Yang roles of MDSCs. Moreover, the capabilities of MDSCs is perhaps addressed all by the textual content material.

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AIFL Blocking Peptide
AF9005-BP 1mg
EUR 195.00
AMPKgamma2 Blocking Peptide
AF9006-BP 1mg
EUR 195.00
ANKRD20 Blocking Peptide
AF9008-BP 1mg
EUR 195.00
APOBEC3A Blocking Peptide
AF9009-BP 1mg
EUR 195.00
ApoOL Blocking Peptide
AF9010-BP 1mg
EUR 195.00
ARHGAP1 Blocking Peptide
AF9011-BP 1mg
EUR 195.00
ARHGAP22 Blocking Peptide
AF9012-BP 1mg
EUR 195.00
ARHGEF19 Blocking Peptide
AF9013-BP 1mg
EUR 195.00
ARMCX1 Blocking Peptide
AF9014-BP 1mg
EUR 195.00
Arrdc1 Blocking Peptide
AF9016-BP 1mg
EUR 195.00
ARRDC2 Blocking Peptide
AF9017-BP 1mg
EUR 195.00
Arrdc4 Blocking Peptide
AF9018-BP 1mg
EUR 195.00
ASF1B Blocking Peptide
AF9022-BP 1mg
EUR 195.00
BAM32 Blocking Peptide
AF9023-BP 1mg
EUR 195.00
BEGAIN Blocking Peptide
AF9024-BP 1mg
EUR 195.00
BRD3 Blocking Peptide
AF9025-BP 1mg
EUR 195.00
BTBD6 Blocking Peptide
AF9026-BP 1mg
EUR 195.00
Cables2 Blocking Peptide
AF9029-BP 1mg
EUR 195.00
CaMKIbeta Blocking Peptide
AF9031-BP 1mg
EUR 195.00
CAS Blocking Peptide
AF9032-BP 1mg
EUR 195.00
CD158f2 Blocking Peptide
AF9037-BP 1mg
EUR 195.00
CD32 Blocking Peptide
AF9038-BP 1mg
EUR 195.00
Cdc16 Blocking Peptide
AF9039-BP 1mg
EUR 195.00
Centrobin Blocking Peptide
AF9040-BP 1mg
EUR 195.00
CEP152 Blocking Peptide
AF9041-BP 1mg
EUR 195.00
CMTM4 Blocking Peptide
AF9042-BP 1mg
EUR 195.00
CNOT2 Blocking Peptide
AF9043-BP 1mg
EUR 195.00
COL19A1 Blocking Peptide
AF9044-BP 1mg
EUR 195.00
COL4A6 Blocking Peptide
AF9045-BP 1mg
EUR 195.00
COL5A3 Blocking Peptide
AF9046-BP 1mg
EUR 195.00
CRSP130 Blocking Peptide
AF9049-BP 1mg
EUR 195.00
CYB561D1 Blocking Peptide
AF9050-BP 1mg
EUR 195.00
CYP4F2 Blocking Peptide
AF9051-BP 1mg
EUR 195.00
Eg5 Blocking Peptide
AF9058-BP 1mg
EUR 195.00
Eps8L3 Blocking Peptide
AF9061-BP 1mg
EUR 195.00
eRF3a Blocking Peptide
AF9062-BP 1mg
EUR 195.00
ETL Blocking Peptide
AF9063-BP 1mg
EUR 195.00
FAM80B Blocking Peptide
AF9064-BP 1mg
EUR 195.00
FBP3 Blocking Peptide
AF9065-BP 1mg
EUR 195.00
FoxR1 Blocking Peptide
AF9067-BP 1mg
EUR 195.00
GAAP Blocking Peptide
AF9068-BP 1mg
EUR 195.00
GALR3 Blocking Peptide
AF9069-BP 1mg
EUR 195.00
GAS3 Blocking Peptide
AF9070-BP 1mg
EUR 195.00
GBP4 Blocking Peptide
AF9071-BP 1mg
EUR 195.00
GPR124 Blocking Peptide
AF9073-BP 1mg
EUR 195.00
GPR139 Blocking Peptide
AF9074-BP 1mg
EUR 195.00
GPR41 Blocking Peptide
AF9075-BP 1mg
EUR 195.00
GPR50 Blocking Peptide
AF9076-BP 1mg
EUR 195.00
GPRC5C Blocking Peptide
AF9077-BP 1mg
EUR 195.00
Grap Blocking Peptide
AF9079-BP 1mg
EUR 195.00
GRB10 Blocking Peptide
AF9080-BP 1mg
EUR 195.00
GRIN2 Blocking Peptide
AF9081-BP 1mg
EUR 195.00
GS28 Blocking Peptide
AF9082-BP 1mg
EUR 195.00
HABP2 Blocking Peptide
AF9083-BP 1mg
EUR 195.00
HORMAD1 Blocking Peptide
AF9088-BP 1mg
EUR 195.00
HoxD10 Blocking Peptide
AF9089-BP 1mg
EUR 195.00
HoxD8 Blocking Peptide
AF9090-BP 1mg
EUR 195.00
HRT2 Blocking Peptide
AF9092-BP 1mg
EUR 195.00
INTS2 Blocking Peptide
AF9098-BP 1mg
EUR 195.00
KCNT1 Blocking Peptide
AF9099-BP 1mg
EUR 195.00
KIF13B Blocking Peptide
AF9100-BP 1mg
EUR 195.00
KIR3.1 Blocking Peptide
AF9101-BP 1mg
EUR 195.00
KIR3.4 Blocking Peptide
AF9102-BP 1mg
EUR 195.00
LHR Blocking Peptide
AF9104-BP 1mg
EUR 195.00
LONP2 Blocking Peptide
AF9105-BP 1mg
EUR 195.00
LRP10 Blocking Peptide
AF9106-BP 1mg
EUR 195.00
LUC7L2 Blocking Peptide
AF9107-BP 1mg
EUR 195.00
Matriptase Blocking Peptide
AF9109-BP 1mg
EUR 195.00
MCT12 Blocking Peptide
AF9110-BP 1mg
EUR 195.00
ME2 Blocking Peptide
AF9111-BP 1mg
EUR 195.00
MINK1 Blocking Peptide
AF9112-BP 1mg
EUR 195.00
Mob3C Blocking Peptide
AF9114-BP 1mg
EUR 195.00
MPP1 Blocking Peptide
AF9115-BP 1mg
EUR 195.00
MRCKbeta Blocking Peptide
AF9116-BP 1mg
EUR 195.00
MRGF Blocking Peptide
AF9117-BP 1mg
EUR 195.00
NDUFS5 Blocking Peptide
AF9124-BP 1mg
EUR 195.00
Nek9 Blocking Peptide
AF9125-BP 1mg
EUR 195.00
NFATc2IP Blocking Peptide
AF9128-BP 1mg
EUR 195.00
NFRKB Blocking Peptide
AF9129-BP 1mg
EUR 195.00
Nicalin Blocking Peptide
AF9130-BP 1mg
EUR 195.00
Nidogen Blocking Peptide
AF9131-BP 1mg
EUR 195.00
NIPA Blocking Peptide
AF9132-BP 1mg
EUR 195.00
NMUR1 Blocking Peptide
AF9133-BP 1mg
EUR 195.00
Nox3 Blocking Peptide
AF9134-BP 1mg
EUR 195.00
NRIP3 Blocking Peptide
AF9135-BP 1mg
EUR 195.00
OMG Blocking Peptide
AF9146-BP 1mg
EUR 195.00
OTUB2 Blocking Peptide
AF9147-BP 1mg
EUR 195.00
Oxr1 Blocking Peptide
AF9148-BP 1mg
EUR 195.00
PDE10A Blocking Peptide
AF9150-BP 1mg
EUR 195.00
PEG3 Blocking Peptide
AF9152-BP 1mg
EUR 195.00
Peropsin Blocking Peptide
AF9153-BP 1mg
EUR 195.00
PHF3 Blocking Peptide
AF9154-BP 1mg
EUR 195.00
PHKB Blocking Peptide
AF9156-BP 1mg
EUR 195.00
PIG3 Blocking Peptide
AF9159-BP 1mg
EUR 195.00
PIPOX Blocking Peptide
AF9160-BP 1mg
EUR 195.00
PLA1A Blocking Peptide
AF9162-BP 1mg
EUR 195.00
Pmp24 Blocking Peptide
AF9163-BP 1mg
EUR 195.00
PNPase Blocking Peptide
AF9164-BP 1mg
EUR 195.00
POLR3B Blocking Peptide
AF9165-BP 1mg
EUR 195.00
POLR3E Blocking Peptide
AF9166-BP 1mg
EUR 195.00
PRPF31 Blocking Peptide
AF9169-BP 1mg
EUR 195.00
QSK Blocking Peptide
AF9172-BP 1mg
EUR 195.00
RAB3IP Blocking Peptide
AF9176-BP 1mg
EUR 195.00
Rabr Blocking Peptide
AF9177-BP 1mg
EUR 195.00
RBM34 Blocking Peptide
AF9179-BP 1mg
EUR 195.00
RCC2 Blocking Peptide
AF9180-BP 1mg
EUR 195.00
RFX3 Blocking Peptide
AF9181-BP 1mg
EUR 195.00
RHOBTB3 Blocking Peptide
AF9183-BP 1mg
EUR 195.00
Rim4 Blocking Peptide
AF9186-BP 1mg
EUR 195.00
RREB1 Blocking Peptide
AF9187-BP 1mg
EUR 195.00
RTCD1 Blocking Peptide
AF9190-BP 1mg
EUR 195.00
RXRgamma Blocking Peptide
AF9191-BP 1mg
EUR 195.00
SCAF1 Blocking Peptide
AF9193-BP 1mg
EUR 195.00
SCAND1 Blocking Peptide
AF9194-BP 1mg
EUR 195.00
Separase Blocking Peptide
AF9195-BP 1mg
EUR 195.00
SH3BGR Blocking Peptide
AF9198-BP 1mg
EUR 195.00
Sin3B Blocking Peptide
AF9199-BP 1mg
EUR 195.00
SphK2 Blocking Peptide
AF9201-BP 1mg
EUR 195.00
STAM2 Blocking Peptide
AF9203-BP 1mg
EUR 195.00
StIp1 Blocking Peptide
AF9204-BP 1mg
EUR 195.00
SUHW1 Blocking Peptide
AF9205-BP 1mg
EUR 195.00
SYT Blocking Peptide
AF9206-BP 1mg
EUR 195.00
TAB182 Blocking Peptide
AF9207-BP 1mg
EUR 195.00

MRGPRX2 indicators its significance in cutaneous mast cell biology: Does MRGPRX2 be part of mast cells and atopic dermatitis?

 

The invention of MRGPRX2 marks a necessary change in MC biology, explaining non-IgE-mediated scientific phenomena relying on MCs. As receptor for quite a few remedy, MRGPRX2 is important to drug-induced hypersensitivity.

Nonetheless, not solely remedy, however moreover endogenous mediators like neuropeptides and host safety peptides activate MRGPRX2, suggesting its broad affect in cutaneous pathophysiology.

Proper right here, we give a brief overview of MRGPRX2 and its regulation by microenvironmental stimuli, which assist MCs and shall be altered in pores and pores and skin points, and briefly contact on the purposeful packages elicited by MRGPRX2 ligation. Analysis in Mrgprb2-deficient mice (the murine ortholog) help illuminate MRGPRX2’s function in effectively being and sickness.

Present advances on this model assist the long-suspected operational unit between MCs and nerves, with MRGPRX2 being an vital component. Based on the restricted proof for a big contribution of FcεRI/IgE-activated MCs to atopic dermatitis (AD), we develop the hypothesis that MRGPRX2 constitutes the missing hyperlink connecting MCs and AD, a minimum of in chosen endotypes.

Help comes from the multifold changes inside the MC-neuronal system of AD pores and pores and skin (e.g. bigger density of MCs and nearer connections between MCs and nerves, elevated PAR-2/Substance P).

We theorize that these deregulations suffice to impress AD, nonetheless exterior triggers, numerous which activating MRGPRX2 themselves (e.g. Staphylococcus aureus) extra feed into the loop. Itch, most likely probably the most burdensome hallmark of AD, is usually non-histaminergic nonetheless tryptase-dependent, and tryptase is preferentially launched upon MRGPRX2 activation. On account of MRGPRX2 is a very energetic evaluation space, a couple of of the current gaps are susceptible to be closed shortly.

Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Preliminary Part

 

By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that preserve distinctive contractile properties. Their dynamic nature is vital for neuronal biology along with the establishment of polarity, progress cone formation and motility, axon progress all through enchancment (and axon regeneration inside the grownup), radial and longitudinal axonal stress, and synapse formation and efficiency.

On this overview, we speak in regards to the current information on the spatial distribution and efficiency of the actomyosin cytoskeleton in quite a few axonal compartments.

We highlight a couple of of the plain contradictions and open questions inside the space, along with the place of NMII inside the regulation of axon progress and regeneration, the possibility that NMII structural affiliation alongside the axon shaft would possibly administration every radial and longitudinal contractility, and the mechanism and purposeful goal underlying NMII enrichment inside the axon preliminary part.

With the advances in reside cell imaging and super choice microscopy, it is anticipated that inside the near future the spatial distribution of NMII inside the axon, and the mechanisms by which it participates in axonal biology is perhaps extra untangled.

D-Glucuronic acid, free acid

GB0482 5g
EUR 155.16
  • Product category: Biochemicals/Carbohydrates/Sugars

DL-Maleic acid (Toxilic acid)

MA0333 250g
EUR 64.50
  • Product category: Biochemicals/Biological Buffers/Buffer Related

Folic Acid

AG062 1 mg
EUR 523.00

Ferulic Acid

AG130 1 mg
EUR 523.00

Benzoic Acid

AG153 1 mg
EUR 523.00

Trichlorophenoxyacetic Acid

AG169 1 mg
EUR 523.00

Tenuazonic acid

AG183 1 mg
EUR 523.00

Glycochenodeoxycholic acid

AG216 1 mg
EUR 523.00

Arsanilic acid

AG255 1 mg
EUR 523.00

Gibberellic acid

AG268 1 mg
EUR 523.00

Cholic acid

CB0298 50g
EUR 79.67
  • Product category: Biochemicals/Detergents/Surfactants

Casamino Acid

CB3060 100g
EUR 62.18
  • Product category: Culture Media/Supplements

Ethacrynic Acid

C4125-1000 1 g
EUR 121.00

Ethacrynic Acid

C4125-10000 10 g
EUR 682.00

Ethacrynic Acid

C4125-5000 5 g
EUR 383.00

Asterric Acid

C4549-1 1 mg
EUR 293.00
Description: IC50: 10 ?M for ET-1 binding to the ETA receptor ofA10 cellsAsterric Acid is an ETA receptor inhibitor. Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells.

Asterric Acid

C4549-5 5 mg
EUR 963.00
Description: IC50: 10 ?M for ET-1 binding to the ETA receptor ofA10 cellsAsterric Acid is an ETA receptor inhibitor. Endothelin (ET), a potent vasoconstrictor/pressor peptide consisting of 21 amino acid residues, was first isolated from the cultures of porcine aortic endothelial cells.

Ascorbic Acid

CA052-010 100g
EUR 77.00

Ascorbic Acid

CA052-050 500g
EUR 131.00

Maslinic Acid

C4832-10 10 mg
EUR 283.00
Description: Maslinic acid is a pentacyclic triterpene existed in the protective wax-like coating of the leaves and fruit of Olea europaea L [1]. Maslinic acid is an inhibitor of NO, H2O2, IL-6 and TNF-?.

Maslinic Acid

C4832-25 25 mg
EUR 561.00
Description: Maslinic acid is a pentacyclic triterpene existed in the protective wax-like coating of the leaves and fruit of Olea europaea L [1]. Maslinic acid is an inhibitor of NO, H2O2, IL-6 and TNF-?.

Maslinic Acid

C4832-5 5 mg
EUR 181.00
Description: Maslinic acid is a pentacyclic triterpene existed in the protective wax-like coating of the leaves and fruit of Olea europaea L [1]. Maslinic acid is an inhibitor of NO, H2O2, IL-6 and TNF-?.

Fusaric Acid

C5062-250 250 mg
EUR 145.00
Description: Fusaric acid is a mycotoxin produced by several species of Fusarium [1]. Mycotoxins are biologically active secondary fungal metabolites found as contaminants of food- and feedstuff. Mycotoxin is capable of causing disease and death in both humans and animals.

Fusaric Acid

C5062-500 500 mg
EUR 224.00
Description: Fusaric acid is a mycotoxin produced by several species of Fusarium [1]. Mycotoxins are biologically active secondary fungal metabolites found as contaminants of food- and feedstuff. Mycotoxin is capable of causing disease and death in both humans and animals.

Tienilic Acid

C5345-10 10 mg
EUR 186.00
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Tienilic Acid

C5345-25 25 mg
EUR 413.00
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Tienilic Acid

C5345-5 5 mg
EUR 131.00
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Tienilic Acid

C5345-50 50 mg
EUR 695.00
Description: Km: 5 microM for CYP 2C9 catalyzing 5-hydroxylation of tienilic acid Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10.Cytochrome P450 enzymes function to metabolize both endogenous and exogenous xenobiotics.

Eicosatetraynoic Acid

C5515-10 10 mg
EUR 158.00
Description: Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1]. Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins.

Eicosatetraynoic Acid

C5515-25 25 mg
EUR 308.00
Description: Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1]. Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins.

Eicosatetraynoic Acid

C5515-50 50 mg
EUR 506.00
Description: Eicosatetraynoic Acid is nonspecific inhibitor of cyclooxygenases and lipoxygenases [1]. Cyclooxygenase (COX) is the key enzyme required for the conversion of arachidonic acid to prostaglandins.

?-Linolenic Acid

C5518-1000 1 g
EUR 261.00
Description: Gamma-linolenic acid is a weak Leukotriene B4 (LTB4) receptor antagonist.Gamma-linolenic acid (GLA), an omega-6 fatty acid, is an essential fatty acid necessary for human health. You have to get them through food.

?-Linolenic Acid

C5518-250 250 mg
EUR 137.00
Description: Gamma-linolenic acid is a weak Leukotriene B4 (LTB4) receptor antagonist.Gamma-linolenic acid (GLA), an omega-6 fatty acid, is an essential fatty acid necessary for human health. You have to get them through food.

Evernic Acid

C5610-100 100 mg
EUR 405.00
Description: Evernic Acid is an inhibitor of two key plasmodial FAS-II enzymes PfFabZ and PfFabIThe Type II fatty acid synthase (FAS) system catalysed fatty acid biosynthesis in most bacteria.

Evernic Acid

C5610-250 250 mg
EUR 760.00
Description: Evernic Acid is an inhibitor of two key plasmodial FAS-II enzymes PfFabZ and PfFabIThe Type II fatty acid synthase (FAS) system catalysed fatty acid biosynthesis in most bacteria.

Evernic Acid

C5610-50 50 mg
EUR 263.00
Description: Evernic Acid is an inhibitor of two key plasmodial FAS-II enzymes PfFabZ and PfFabIThe Type II fatty acid synthase (FAS) system catalysed fatty acid biosynthesis in most bacteria.

?-Guanidinoglutaric Acid

C5708-100 100 mg
EUR 458.00
Description: ?-Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2.69 ?M [1].

?-Guanidinoglutaric Acid

C5708-50 50 mg
EUR 283.00
Description: ?-Guanidinoglutaric Acid is a novel nitric oxide synthase inhibitor with Ki value of 2.69 ?M [1].

Benzoic Acid

B1676-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Benzoic acid is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.

Benzoic Acid

B1676-50 50 mg
EUR 128.00
Description: Benzoic acid is a colorless crystalline solid and a simple aromatic carboxylic acid, used as a food preservative.

Clofibric Acid

B1711-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Clofibric acid is a PPAR? agonist and hypolipidemic agent.

Clofibric Acid

B1711-50 50 mg
EUR 128.00
Description: Clofibric acid is a PPAR? agonist and hypolipidemic agent.

Flufenamic acid

B1760-100000 100 g
EUR 187.00
Description: Flufenamic acid

Flufenamic acid

B1760-250000 250 g
EUR 325.00
Description: Flufenamic acid

Flufenamic acid

B1760-50000 50 g
EUR 125.00
Description: Flufenamic acid

Tranexamic Acid

B1858-10000 10 g
EUR 142.00
Description: Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

Tranexamic Acid

B1858-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

Tranexamic Acid

B1858-50 50 mg
EUR 96.00
Description: Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

Tranexamic Acid

B1858-5000 5 g
EUR 108.00
Description: Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM.

Tropodithietic Acid

B1867-1
EUR 251.00

Oseltamivir Acid

B1886-1
EUR 131.00

Oseltamivir Acid

B1886-5
EUR 349.00

Obeticholic Acid

B1898-25
EUR 381.00

Obeticholic Acid

B1898-5
EUR 142.00

Chenodeoxycholic Acid

B1908-100 100 mg
EUR 96.00
Description: Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors(FXR) involved in cholesterol metabolism.

Chenodeoxycholic Acid

B1908-1000 1 g
EUR 108.00
Description: Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors(FXR) involved in cholesterol metabolism.

Chenodeoxycholic Acid

B1908-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors(FXR) involved in cholesterol metabolism.

Chenodeoxycholic Acid

B1908-5000 5 g
EUR 224.00
Description: Chenodeoxycholic Acid (CDCA), is a hydrophobic primary bile acid that activates nuclear receptors(FXR) involved in cholesterol metabolism.

Bempedoic acid

B1913-25
EUR 544.00

Bempedoic acid

B1913-5
EUR 175.00

Cyclamic acid

B1921-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.

Cyclamic acid

B1921-50 50 mg
EUR 128.00
Description: Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.

Cyclamic acid

B1921-S Evaluation Sample
EUR 81.00
Description: Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners.

Mycophenolic acid

B1981-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Mycophenolic acid

Mycophenolic acid

B1981-50 50 mg
EUR 128.00
Description: Mycophenolic acid

Mycophenolic acid

B1981-S Evaluation Sample
EUR 81.00
Description: Mycophenolic acid

Nalidixic acid

B1985-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Nalidixic acid

Nalidixic acid

B1985-50 50 mg
EUR 128.00
Description: Nalidixic acid

Nalidixic acid

B1985-S Evaluation Sample
EUR 81.00
Description: Nalidixic acid

Nicotinic Acid

B1987-100000 100 g
EUR 108.00
Description: Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.

Nicotinic Acid

B1987-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.

Nicotinic Acid

B1987-50 50 mg
EUR 96.00
Description: Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.

Nicotinic Acid

B1987-500000 500 g
EUR 224.00
Description: Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.

Aspterric acid

B2233-1
EUR 370.00

Aspterric acid

B2233-5
EUR 1240.00

Gibberellic acid

B2234-1G
EUR 120.00

Gibberellic acid

B2234-5G
EUR 327.00

Fusidic acid

B2392-100
EUR 120.00

Fusidic acid

B2392-500
EUR 240.00

Carglumic acid

B2447-10
EUR 109.00

Carglumic acid

B2447-50
EUR 229.00

Eicosapentaenoic Acid

B3464-100 100 mg
EUR 116.00

Grifolic acid

B5647-.5 500 µg
EUR 142.00

Grifolic acid

B5647-1 1 mg
EUR 203.00

Suberohydroxamic Acid

B5976-1000 1 g
EUR 241.00
Description: Suberohydroxamic Acid (Suberoyl bis-hydroxamic acid, SBHA) is an inhibitor of HDAC with ID50 values of 0.25 and 0.30 ?M for HDAC1 and HDAC3, respectively [1].

Suberohydroxamic Acid

B5976-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Suberohydroxamic Acid (Suberoyl bis-hydroxamic acid, SBHA) is an inhibitor of HDAC with ID50 values of 0.25 and 0.30 ?M for HDAC1 and HDAC3, respectively [1].

Suberohydroxamic Acid

B5976-500 500 mg
EUR 166.00
Description: Suberohydroxamic Acid (Suberoyl bis-hydroxamic acid, SBHA) is an inhibitor of HDAC with ID50 values of 0.25 and 0.30 ?M for HDAC1 and HDAC3, respectively [1].

Fenofibric acid

B6128-100 100 mg
EUR 128.00

Fenofibric acid

B6128-500 500 mg
EUR 290.00

Oxolinic acid

B6129-10000 10 g
EUR 206.00
Description: IC50: 4.3 ?M for dopamine uptakeOxolinic acid is a quinolone antibiotic inhibiting bacterial DNA gyrase.DNA gyrase, an enzyme within the class of topoisomerase, relieves strain while double-stranded DNA is being unwound by helicase.

Oxolinic acid

B6129-25000 25 g
EUR 398.00
Description: IC50: 4.3 ?M for dopamine uptakeOxolinic acid is a quinolone antibiotic inhibiting bacterial DNA gyrase.DNA gyrase, an enzyme within the class of topoisomerase, relieves strain while double-stranded DNA is being unwound by helicase.

Oxolinic acid

B6129-5000 5 g
EUR 137.00
Description: IC50: 4.3 ?M for dopamine uptakeOxolinic acid is a quinolone antibiotic inhibiting bacterial DNA gyrase.DNA gyrase, an enzyme within the class of topoisomerase, relieves strain while double-stranded DNA is being unwound by helicase.

Lauric Acid

B6155-250000 250 g
EUR 119.00
Description: Lauric acid, a saturated medium-chain fatty acid with a 12-carbon backbone, is naturally found in various plant and animal fats and oils, which is a major component of palm kernel oil and coconut oil.

Dihydrokainic acid

B6208-1 1 mg
EUR 187.00

Dihydrokainic acid

B6208-10 10 mg
EUR 334.00

Dihydrokainic acid

B6208-50 50 mg
EUR 1243.00

Homoquinolinic acid

B6223-10 10 mg
EUR 357.00

Homoquinolinic acid

B6223-50 50 mg
EUR 1340.00

Kainic acid

B6226-1 1 mg
EUR 171.00
Description: Kainic acid is a selective agonist of kainate receptor [1]. Kainate receptor is an ionotropic receptor that responds to glutamate.

Kainic acid

B6226-10 10 mg
EUR 308.00
Description: Kainic acid is a selective agonist of kainate receptor [1]. Kainate receptor is an ionotropic receptor that responds to glutamate.

Kainic acid

B6226-50 50 mg
EUR 1136.00
Description: Kainic acid is a selective agonist of kainate receptor [1]. Kainate receptor is an ionotropic receptor that responds to glutamate.

Kynurenic acid

B6227-5000 5 g
EUR 196.00

Quinolinic acid

B6228-1000 1 g
EUR 132.00

Quinolinic acid

B6228-5.1 10 mM (in 1mL DMSO)
EUR 108.00

(±)-Nipecotic acid

B6231-100 100 mg
EUR 177.00

Domoic acid

B6241-1 1 mg
EUR 350.00

Ibotenic acid

B6246-1 1 mg
EUR 115.00

Ibotenic acid

B6246-25 25 mg
EUR 1276.00

Ibotenic acid

B6246-5 5 mg
EUR 328.00

Spaglumic acid

B6288-10 10 mg
EUR 139.00

Spaglumic acid

B6288-50 50 mg
EUR 231.00

Cyclopiazonic acid

B6647-10 10 mg
EUR 187.00

Cyclopiazonic acid

B6647-5 5 mg
EUR 129.00

(-)-Terreic acid

B6724-10 10 mg
EUR 350.00
Description: IC50: about 100 ?M for binding of GST-BtkPH to PKC, about 30 ?M for association of Btk with PKCbII, about 10 ?M for JNK1 activity, and about 7 ?M for TNF-a and about 3 ?M for IL-2.

Salicylic acid

B1092-10000 10 g
EUR 119.00
Description: Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity.

Salicylic acid

B1092-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity.

Salicylic acid

B1092-50000 50 g
EUR 142.00
Description: Salicylic acid is a natural product extract from Willow bark, well known as an antiinflammatory inhibitor of cyclooxygenase activity.

Orotic acid

B1147-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Orotic acid (OA) is an intermediate in pyrimidine metabolism.

Orotic acid

B1147-500 500 mg
EUR 108.00
Description: Orotic acid (OA) is an intermediate in pyrimidine metabolism.

Ellagic Acid

B1154-100
EUR 109.00

Ellagic Acid

B1154-500
EUR 240.00

Valproic acid

B1251-10000 10 g
EUR 189.00
Description: Valproic acid is an inhibitor of HDAC1 with IC50 value of 0.4mM [1].Valproic acid (VPA) is a branched short-chain fatty acid. It is previously synthesized and used as an inert solvent of organic compounds.

Valproic acid

B1251-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Valproic acid is an inhibitor of HDAC1 with IC50 value of 0.4mM [1].Valproic acid (VPA) is a branched short-chain fatty acid. It is previously synthesized and used as an inert solvent of organic compounds.

Valproic acid

B1251-5000 5 g
EUR 142.00
Description: Valproic acid is an inhibitor of HDAC1 with IC50 value of 0.4mM [1].Valproic acid (VPA) is a branched short-chain fatty acid. It is previously synthesized and used as an inert solvent of organic compounds.

Mefenamic Acid

B1449-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Mefenamic acid is a non-steroidal anti-inflammatory agent, which is an inhibitor of cyclooxygenase.Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. M

Mefenamic Acid

B1449-50 50 mg
EUR 128.00
Description: Mefenamic acid is a non-steroidal anti-inflammatory agent, which is an inhibitor of cyclooxygenase.Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. M

Mefenamic Acid

B1449-S Evaluation Sample
EUR 81.00
Description: Mefenamic acid is a non-steroidal anti-inflammatory agent, which is an inhibitor of cyclooxygenase.Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. M

Tolfenamic Acid

B1455-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs).Tolfenamic acid is a NSAID. Tolfenamic acid treatment inhibited cell growth and induced apoptosis as measured by caspase activity and bioelectric impedance. Tolfena

Tolfenamic Acid

B1455-50 50 mg
EUR 102.00
Description: Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs).Tolfenamic acid is a NSAID. Tolfenamic acid treatment inhibited cell growth and induced apoptosis as measured by caspase activity and bioelectric impedance. Tolfena

Tolfenamic Acid

B1455-S Evaluation Sample
EUR 81.00
Description: Tolfenamic acid (TA) is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs).Tolfenamic acid is a NSAID. Tolfenamic acid treatment inhibited cell growth and induced apoptosis as measured by caspase activity and bioelectric impedance. Tolfena

Niflumic acid

B1530-5.1 10 mM (in 1mL DMSO)
EUR 108.00
Description: Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.Niflumic acid, an inhibitor of calcium-activated chloride currents. Niflumic acid does not block directly calciu

Niflumic acid

B1530-50 50 mg
EUR 128.00
Description: Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.Niflumic acid, an inhibitor of calcium-activated chloride currents. Niflumic acid does not block directly calciu

Niflumic acid

B1530-S Evaluation Sample
EUR 81.00
Description: Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.Niflumic acid, an inhibitor of calcium-activated chloride currents. Niflumic acid does not block directly calciu

Obeticholic Acid

B4888-100 100 mg
EUR 595.00
Description: Obeticholic Acid (6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747) is a potent and selective agonist of FXR with EC50 value of 99 nM [1].

Obeticholic Acid

B4888-25 25 mg
EUR 282.00
Description: Obeticholic Acid (6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747) is a potent and selective agonist of FXR with EC50 value of 99 nM [1].

Obeticholic Acid

B4888-5 5 mg
EUR 108.00
Description: Obeticholic Acid (6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747) is a potent and selective agonist of FXR with EC50 value of 99 nM [1].

Obeticholic Acid

B4888-5.1 10 mM (in 1mL DMSO)
EUR 113.00
Description: Obeticholic Acid (6alpha-ethyl-chenodeoxycholic acid, 6-ECDCA, INT-747) is a potent and selective agonist of FXR with EC50 value of 99 nM [1].

Valerenic acid

B7254-1 1 mg
EUR 268.00

Citric acid

B7297-500000 500 g
EUR 112.00

Boric acid

B7305-500000 500 g
EUR 125.00

Cinnabarinic acid

B7592-10 10 mg
EUR 202.00

Cinnabarinic acid

B7592-50 50 mg
EUR 732.00

Xanthurenic acid

B7593-10000 10 g
EUR 537.00

Xanthurenic acid

B7593-5000 5 g
EUR 311.00

Folinic acid

B7886-10 10 mg
EUR 108.00

Folinic acid

B7886-50 50 mg
EUR 166.00

Glyoxylic acid

B7888-100 100 mg
EUR 108.00

Glyoxylic acid

B7888-500 500 mg
EUR 166.00

Folic Acid

AT062 1mg
EUR 945.00

Ferulic Acid

AT130 1mg
EUR 1790.00

Benzoic Acid

AT153 1mg
EUR 1368.00

Trichlorophenoxyacetic Acid

AT169 1mg
EUR 1368.00

Tenuazonic acid

AT183 1mg
EUR 1114.00

Glycochenodeoxycholic acid

AT216 1mg
EUR 1114.00

Arsanilic acid

AT255 1mg
EUR 1368.00

Gibberellic acid

AT268 1mg
EUR 1368.00

Itaconic acid

B7891-100 100 mg
EUR 108.00

Itaconic acid

B7891-500 500 mg
EUR 166.00

Ketoisovaleric acid

B7892-100 100 mg
EUR 108.00

Ketoisovaleric acid

B7892-500 500 mg
EUR 166.00

Lactic acid

B7893-100 100 mg
EUR 108.00

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